Neuromedin B receptor

NMBR
Identifiers
Aliases	NMBR, BB1, NMB-R, neuromedin B receptor, BB1R, BRS1
External IDs	OMIM: 162341; MGI: 1100525; HomoloGene: 20560; GeneCards: NMBR; OMA:NMBR - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	142,147,122 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; prefrontal cortex; ; olfactory zone of nasal mucosa; ; ganglionic eminence; ; right uterine tube; ; caudate nucleus; ; gonad; ; putamen; ; nucleus accumbens;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; signal transducer activity; G protein-coupled receptor activity; bombesin receptor activity;
Cellular component	integral component of plasma membrane; membrane; integral component of membrane; plasma membrane; cytosol;
Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway; bombesin receptor signaling pathway; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4829
	18101
	ENSG00000135577
	ENSMUSG00000019865
	P28336
	O54799
	NM_002511; NM_001324307; NM_001324308
	NM_008703
	NP_001311236; NP_001311237; NP_002502
	NP_032729
	Wikidata
View/Edit Human	View/Edit Mouse

The neuromedin B receptor (NMBR), now known as BB₁ ^[4] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.^[5] In humans, this protein is encoded by the NMBR gene.

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135577 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Bombesin Receptors: BB₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2013-10-04. Retrieved 2007-10-25.
^ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.
^ "Entrez Gene: NMBR neuromedin B receptor".