Neuromedin U

Neuromedin U
Identifiers
SymbolNMU
NCBI gene10874
HGNC7859
OMIM605103
RefSeqNM_006681
UniProtP48645
Other data
LocusChr. 4 q12
Search for
StructuresSwiss-model
DomainsInterPro

Neuromedin U (NmU or NMU) is a neuropeptide found in the brain of humans and other mammals, which has a number of diverse functions including contraction of smooth muscle, regulation of blood pressure, pain perception, appetite, bone growth, and hormone release. It was first isolated from the spinal cord in 1985, and named after its ability to cause smooth muscle contraction in the uterus.[1][2][3][4][5][6][7][8]

  1. ^ Brighton PJ, Szekeres PG, Willars GB (2004). "Neuromedin U and its receptors: structure, function, and physiological roles". Pharmacol. Rev. 56 (2): 231–48. doi:10.1124/pr.56.2.3. PMID 15169928. S2CID 884735.
  2. ^ Torres R, Croll SD, Vercollone J, Reinhardt J, Griffiths J, Zabski S, Anderson KD, Adams NC, Gowen L, Sleeman MW, Valenzuela DM, Wiegand SJ, Yancopoulos GD, Murphy AJ (August 2007). "Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses". Pain. 130 (3): 267–78. doi:10.1016/j.pain.2007.01.036. PMID 17379411. S2CID 23617159.
  3. ^ Novak CM, Zhang M, Levine JA (September 2007). "Sensitivity of the hypothalamic paraventricular nucleus to the locomotor-activating effects of neuromedin U in obesity". Brain Research. 1169: 57–68. doi:10.1016/j.brainres.2007.06.055. PMC 2735201. PMID 17706946.
  4. ^ Vigo E, Roa J, Pineda R, Castellano JM, Navarro VM, Aguilar E, Pinilla L, Tena-Sempere M (November 2007). "Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod". American Journal of Physiology. Endocrinology and Metabolism. 293 (5): E1265–73. doi:10.1152/ajpendo.00425.2007. PMID 17726140.
  5. ^ Iwai T, Iinuma Y, Kodani R, Oka J (May 2008). "Neuromedin U inhibits inflammation-mediated memory impairment and neuronal cell-death in rodents". Neuroscience Research. 61 (1): 113–9. doi:10.1016/j.neures.2008.01.018. PMID 18336945. S2CID 25260405.
  6. ^ Brighton PJ, Wise A, Dass NB, Willars GB (April 2008). "Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissue". The Journal of Pharmacology and Experimental Therapeutics. 325 (1): 154–64. doi:10.1124/jpet.107.132803. PMID 18180374. S2CID 33931881.
  7. ^ Tanida M, Satomi J, Shen J, Nagai K (February 2009). "Autonomic and cardiovascular effects of central neuromedin U in rats". Physiology & Behavior. 96 (2): 282–8. doi:10.1016/j.physbeh.2008.10.008. PMID 18977236. S2CID 38382442.
  8. ^ Mitchell JD, Maguire JJ, Kuc RE, Davenport AP (February 2009). "Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system". Cardiovascular Research. 81 (2): 353–61. doi:10.1093/cvr/cvn302. PMID 18987052.