Neuromyotonia

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Neuromyotonia
Other names	Isaacs syndrome, Isaacs-Mertens syndrome
Specialty	Neurology, neuromuscular medicine

Neuromyotonia (NMT) is a form of peripheral nerve hyperexcitability that causes spontaneous muscular activity resulting from repetitive motor unit action potentials of peripheral origin. NMT along with Morvan's syndrome are the most severe types in the Peripheral Nerve Hyperexciteability spectrum. Example of two more common and less severe syndromes in the spectrum are cramp fasciculation syndrome and benign fasciculation syndrome.^[1] NMT can have both hereditary and acquired (non-inherited) forms. The prevalence of NMT is unknown.^[2]