Neurotensin receptor

neurotensin receptor 1 (high affinity)
Identifiers
SymbolNTSR1
Alt. symbolsNTR
NCBI gene4923
HGNC8039
OMIM162651
RefSeqNM_002531
UniProtP30989
Other data
LocusChr. 20 q13-20q13
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StructuresSwiss-model
DomainsInterPro
neurotensin receptor 2
Identifiers
SymbolNTSR2
Alt. symbolsNTR2
NCBI gene23620
HGNC8040
OMIM605538
RefSeqNM_012344
UniProtO95665
Other data
LocusChr. 2 p25.1
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StructuresSwiss-model
DomainsInterPro
sortilin 1
Identifiers
SymbolSORT1
Alt. symbolsGp95, NT3
NCBI gene6272
HGNC11186
OMIM602458
RefSeqNM_002959
UniProtQ99523
Other data
LocusChr. 1 p21.3-1p13.1
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StructuresSwiss-model
DomainsInterPro

Neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin.[1][2] Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. Numerous crystal structures have been reported for the neurotensin receptor 1 (NTS1).[3] The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.

  1. ^ Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors". Trends Pharmacol. Sci. 20 (7): 302–309. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.
  2. ^ Pelaprat D (2006). "Interactions between neurotensin receptors and G proteins". Peptides. 27 (10): 2476–2487. doi:10.1016/j.peptides.2006.04.027. PMID 16919370. S2CID 21730838.
  3. ^ Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PR, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A (January 2021). "Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism". Science Advances. 7 (5): eabe5504. Bibcode:2021SciA....7.5504D. doi:10.1126/sciadv.abe5504. PMC 7840143. PMID 33571132.