Neutral amino acid transporter A

SLC1A4
Identifiers
Aliases	SLC1A4, ASCT1, SATT, solute carrier family 1 member 4
External IDs	OMIM: 600229; MGI: 2135601; HomoloGene: 20655; GeneCards: SLC1A4; OMA:SLC1A4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	65,023,865 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	20,282,713 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; sperm; ; glutes; ; spinal ganglia; ; entorhinal cortex; ; internal globus pallidus; ; nucleus accumbens; ; external globus pallidus; ; Skeletal muscle tissue of biceps brachii; ; middle temporal gyrus;
	Top expressed in
	supraoptic nucleus; ; paraventricular nucleus of hypothalamus; ; arcuate nucleus; ; ascending aorta; ; crypt of lieberkuhn of small intestine; ; aortic valve; ; fossa; ; median eminence; ; deep cerebellar nuclei; ; medial vestibular nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	L-glutamine transmembrane transporter activity; L-threonine transmembrane transporter activity; L-proline transmembrane transporter activity; L-serine transmembrane transporter activity; L-hydroxyproline transmembrane transporter activity; L-cystine transmembrane transporter activity; neutral amino acid transmembrane transporter activity; L-alanine transmembrane transporter activity; symporter activity; chloride channel activity; amino acid transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; melanosome; plasma membrane; integral component of plasma membrane; cell surface; soma; dendrite; extracellular exosome; intermediate filament; centrosome; microtubule organizing center;
Biological process	synaptic transmission, glutamatergic; cognition; L-alanine transport; proline transport; hydroxyproline transport; amino acid transport; L-cystine transport; L-serine transport; glutamine transport; threonine transport; chloride transmembrane transport; amino acid transmembrane transport; proline transmembrane transport; transmembrane transport; chloride transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	6509
	55963
	ENSG00000115902
	ENSMUSG00000020142
	P43007
	O35874
	NM_001135581; NM_001193493; NM_003038; NM_001348406; NM_001348407
	NM_018861
	NP_001180422; NP_003029; NP_001335335; NP_001335336
	NP_061349
	Wikidata
View/Edit Human	View/Edit Mouse

Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.^[5]^[6]^[7] In humans, it is expressed in the brain, lung, skeletal muscle, intestine and kidney.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115902 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020142 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hofmann K, Düker M, Fink T, Lichter P, Stoffel W (November 1994). "Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15". Genomics. 24 (1): 20–26. doi:10.1006/geno.1994.1577. PMID 7896285.
^ Zerangue N, Kavanaugh MP (November 1996). "ASCT-1 is a neutral amino acid exchanger with chloride channel activity". The Journal of Biological Chemistry. 271 (45): 27991–27994. doi:10.1074/jbc.271.45.27991. PMID 8910405.
^ "Entrez Gene: SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4".
^ Freidman N, Chen I, Wu Q, Briot C, Holst J, Font J, et al. (June 2020). "Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer". Neurochemical Research. 45 (6): 1268–1286. doi:10.1007/s11064-019-02934-x. PMID 31981058.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115902 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020142 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7896285-5] Hofmann K, Düker M, Fink T, Lichter P, Stoffel W (November 1994). "Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15". Genomics. 24 (1): 20–26. doi:10.1006/geno.1994.1577. PMID 7896285.

[pmid8910405-6] Zerangue N, Kavanaugh MP (November 1996). "ASCT-1 is a neutral amino acid exchanger with chloride channel activity". The Journal of Biological Chemistry. 271 (45): 27991–27994. doi:10.1074/jbc.271.45.27991. PMID 8910405.

[entrez-7] "Entrez Gene: SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4".

[8] Freidman N, Chen I, Wu Q, Briot C, Holst J, Font J, et al. (June 2020). "Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer". Neurochemical Research. 45 (6): 1268–1286. doi:10.1007/s11064-019-02934-x. PMID 31981058.

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