Nicholas I of Opole (Polish: Mikołaj I; c. 1424 – 3 July 1476) was a duke of Opole since 1437 (until 1439 with his brother as co-ruler), Duke of Brzeg from 1450, ruler over Kluczbork from 1451 and Duke of Strzelce, Niemodlin and Olesno from 1460.
He was the fourth son of Duke Bolko IV of Opole by his wife Margareta, possibly member of the House of Gorizia.