The Nickajack Expedition in 1794 was a long-running battle fought from late summer to fall between American frontiersmen and the Chickamauga Cherokee. This Cherokee band had resisted the increasing American encroachment into their territory and raided American settlements in the region.
The military expedition was a decisive success for the American settlers of what was then called the Southwest Territory and surrounding regions. It eventually became known to Americans as the "Last Battle of the Cherokee". Other Cherokee defeats followed shortly, and the US forced them to agree to another treaty ceding some of their land. A total of 39 Cherokee chiefs and leaders, including Chickamauga, signed the 1798 Treaty of Tellico, ceding a large territory in East Tennessee to the United States.