Nicolas Perrenot de Granvelle (1486–1550) was a Burgundian politician who served as a close trusted adviser to Emperor Charles V. He was made suzerain of the imperial city of Besançon and held an influential position in the Netherlands. From 1530 until his death he was one of the emperor's most trusted advisers in Germany. He was the father of the cardinal and politician Antoine Perrenot de Granvelle, also a leading Habsburg minister, and built the Palace Granvelle in Besançon.