Nierenstein reaction

Nierenstein reaction
Named after Maximilian Nierenstein
Reaction type Carbon-carbon bond forming reaction

The Nierenstein reaction is an organic reaction describing the conversion of an acid chloride into a haloketone with diazomethane.[1][2] It is an insertion reaction in that the methylene group from the diazomethane is inserted into the carbon-chlorine bond of the acid chloride.

The Nierenstein reaction
The Nierenstein reaction
  1. ^ Clibbens, D.; Nierenstein, M. (1915). "The action of diazomethane on some aromatic acyl chlorides". J. Chem. Soc. 107: 1491. doi:10.1039/CT9150701491.
  2. ^ Bachman, W. E.; Struve, W. S. (1942). "The Arndt-Eistert Reaction". Org. React. 1: 38. (Review)