Benzodiazepine sedative
Nitrazepam Trade names Alodorm, Apodorm, Arem, Cerson, Insoma, Insomin, Mogadon, Nitrados, Nitrazadon, Nitrosun, Nitravet, Ormodon, Paxadorm, Remnos, Epam, and Somnite AHFS /Drugs.com International Drug Names Dependence liability Physical : High Psychological : ModerateAddiction liability Moderate Routes of administration Oral ATC code Legal status
Bioavailability 53–94% Metabolism Hepatic Elimination half-life 16–38 hours Excretion Renal
7-nitro-5-phenyl-1H -benzo[e ][1,4]diazepin-2(3H )-one
CAS Number PubChem CID DrugBank ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.005.151 Formula C 15 H 11 N 3 O 3 Molar mass 281.271 g·mol−1 3D model (JSmol )
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InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)
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Nitrazepam , sold under the brand name Mogadon among others,[ 2] [ 3] is a hypnotic drug of the benzodiazepine class used for short-term relief from severe, disabling anxiety and insomnia .[ 4] It also has sedative (calming) properties,[ 5] as well as amnestic (inducing forgetfulness), anticonvulsant , and skeletal muscle relaxant effects.
It was first synthesized in the late 1950s by a team of researchers at Hoffmann-La Roche in Switzerland.[ 6] It was patented in 1961 and came into medical use in 1965.[ 7]
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16 .
^ "Benzodiazepine Names" . non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2008-12-29 .
^ "INSOMIN tabletti 5 mg" . laaketietokeskus.fi.
^ "Hypnotics and anxiolytics" . BNF. Retrieved 2014-08-14 .
^ Yasui M, Kato A, Kanemasa T, Murata S, Nishitomi K, Koike K, et al. (June 2005). "[Pharmacological profiles of benzodiazepinergic hypnotics and correlations with receptor subtypes]". Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology . 25 (3): 143–151. OCLC 111086408 . PMID 16045197 .
^ "Benzodiazepines" . Release . 2013-04-09. Retrieved 2023-03-22 .
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery . John Wiley & Sons. p. 537. ISBN 9783527607495 .