Nodal homolog is a secretory protein that in humans is encoded by the NODAL gene[5][6] which is located on chromosome 10q22.1.[7] It belongs to the transforming growth factor beta superfamily (TGF-β superfamily). Like many other members of this superfamily it is involved in cell differentiation in early embryogenesis, playing a key role in signal transfer from the primitive node, in the anterior primitive streak, to lateral plate mesoderm (LPM).[8][9]
Nodal signaling is important very early in development for mesoderm and endoderm formation and subsequent organization of left-right axial structures.[10][11][12] In addition, Nodal seems to have important functions in neural patterning, stem cell maintenance[7][12] and many other developmental processes, including left/right handedness.[11][13]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000156574 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037171 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Gebbia M, Ferrero GB, Pilia G, Bassi MT, Aylsworth A, Penman-Splitt M, et al. (November 1997). "X-linked situs abnormalities result from mutations in ZIC3". Nature Genetics. 17 (3): 305–308. doi:10.1038/ng1197-305. PMID 9354794. S2CID 22916101.
- ^ "NODAL - Nodal homolog precursor - Homo sapiens (Human) - NODAL gene & protein". www.uniprot.org. Archived from the original on 30 March 2022. Retrieved 30 March 2022.
- ^ a b Strizzi L, Postovit LM, Margaryan NV, Seftor EA, Abbott DE, Seftor RE, et al. (2008). "Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression". Breast Disease. 29: 91–103. doi:10.3233/bd-2008-29110. PMC 3175751. PMID 19029628.
- ^ Kawasumi A, Nakamura T, Iwai N, Yashiro K, Saijoh Y, Belo JA, et al. (May 2011). "Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos". Developmental Biology. 353 (2): 321–330. doi:10.1016/j.ydbio.2011.03.009. PMC 4134472. PMID 21419113.
- ^ Branford WW, Yost HJ (May 2004). "Nodal signaling: CrypticLefty mechanism of antagonism decoded". Current Biology. 14 (9): R341–R343. Bibcode:2004CBio...14.R341B. doi:10.1016/j.cub.2004.04.020. PMID 15120085.
- ^ "Entrez Gene: NODAL nodal homolog (mouse)".
- ^ a b Dougan ST, Warga RM, Kane DA, Schier AF, Talbot WS (May 2003). "The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm". Development. 130 (9): 1837–1851. doi:10.1242/dev.00400. PMID 12642489.
- ^ a b Shen MM (March 2007). "Nodal signaling: developmental roles and regulation". Development. 134 (6): 1023–1034. doi:10.1242/dev.000166. PMID 17287255.
- ^ Brandler WM, Morris AP, Evans DM, Scerri TS, Kemp JP, Timpson NJ, et al. (September 2013). "Common variants in left/right asymmetry genes and pathways are associated with relative hand skill". PLOS Genetics. 9 (9): e1003751. doi:10.1371/journal.pgen.1003751. PMC 3772043. PMID 24068947.