Noggin (protein)

NOG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M4U
Identifiers
Aliases	NOG, Nog, SYM1, SYNS1, SYNS1A, noggin
External IDs	OMIM: 602991; MGI: 104327; HomoloGene: 3979; GeneCards: NOG; OMA:NOG - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 56,593,699 bp[1] End 56,595,611 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 54.34 cM Start 89,191,464 bp[2] End 89,193,158 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium buccal mucosa cell testicle gonad ventricular zone ganglionic eminence decidua canal of the cervix nucleus accumbens stromal cell of endometrium Top expressed in notochord neural groove neural fold ventricular zone phalanx of second toe muscle of thigh embryo embryonic organizer primary visual cortex somite More reference expression data BioGPS n/a
Gene ontology Molecular function protein homodimerization activity protein binding cytokine binding Cellular component extracellular region extracellular space Biological process positive regulation of glomerulus development pattern specification process axial mesoderm development skeletal system development cell differentiation ureteric bud development negative regulation of astrocyte differentiation pituitary gland development positive regulation of branching involved in ureteric bud morphogenesis lung morphogenesis negative regulation of cartilage development somatic stem cell population maintenance fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation positive regulation of epithelial cell proliferation negative regulation of cytokine activity neural plate morphogenesis negative regulation of cell differentiation anatomical structure formation involved in morphogenesis mesoderm formation negative regulation of apoptotic signaling pathway embryonic digit morphogenesis cellular response to BMP stimulus wound healing in utero embryonic development BMP signaling pathway negative regulation of gene expression somite development negative regulation of osteoblast differentiation embryonic skeletal system development nervous system development axon guidance negative regulation of BMP signaling pathway regulation of BMP signaling pathway multicellular organism development prostatic bud formation limb development central nervous system development cartilage development neural tube closure brain development negative regulation of cell migration notochord morphogenesis cell differentiation in hindbrain mesenchymal cell differentiation regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation neural tube development spinal cord development ureteric bud formation epithelial to mesenchymal transition middle ear morphogenesis embryonic skeletal joint morphogenesis urogenital system development endoderm formation negative regulation of cardiac muscle cell proliferation motor neuron axon guidance dorsal/ventral pattern formation negative regulation of canonical Wnt signaling pathway face morphogenesis positive regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II osteoblast differentiation membranous septum morphogenesis outflow tract morphogenesis endocardial cushion morphogenesis ventricular compact myocardium morphogenesis endoderm development positive regulation of gene expression atrial cardiac muscle tissue morphogenesis negative regulation of pathway-restricted SMAD protein phosphorylation ventricular septum morphogenesis BMP signaling pathway involved in heart development heart trabecula morphogenesis pharyngeal arch artery morphogenesis negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9241 18121 Ensembl ENSG00000183691 ENSMUSG00000048616 UniProt Q13253 P97466 RefSeq (mRNA) NM_005450 NM_008711 RefSeq (protein) NP_005441 NP_032737 Location (UCSC) Chr 17: 56.59 – 56.6 Mb Chr 11: 89.19 – 89.19 Mb PubMed search [3] [4]
Wikidata
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Noggin, also known as NOG, is a protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones. In humans, noggin is encoded by the NOG gene.^[5] The amino acid sequence of human noggin is highly homologous to that of rat, mouse, and Xenopus (an aquatic frog genus).

Noggin is an inhibitor of several bone morphogenetic proteins (BMPs): it inhibits at least BMP2, 4, 5, 6, 7, 13, and 14.^[6]

The protein's name, which is a slang English-language word for "head", was coined in reference to its ability to produce embryos with large heads when exposed at high concentrations.^[7]