Norepinephrine transporter

SLC6A2
Identifiers
Aliases	SLC6A2, NAT1, NET, NET1, SLC6A5, solute carrier family 6 member 2, Norepinephrine transporter, norepinephrine transporter gene
External IDs	OMIM: 163970; MGI: 1270850; HomoloGene: 816; GeneCards: SLC6A2; OMA:SLC6A2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	55,707,645 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	93,728,295 bp
RNA expression pattern
	Top expressed in
	placenta; ; buccal mucosa cell; ; decidua; ; superior vestibular nucleus; ; caput epididymis; ; skin of thigh; ; glomerulus; ; metanephric glomerulus; ; left testis; ; nipple;
	Top expressed in
	carotid body; ; decidua; ; gastrula; ; right lung lobe; ; maxillary nerve; ; external carotid artery; ; skin of external ear; ; upper lip; ; superior cervical ganglion; ; perirhinal cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	dopamine:sodium symporter activity; neurotransmitter:sodium symporter activity; norepinephrine:sodium symporter activity; monoamine transmembrane transporter activity; protein binding; symporter activity; metal ion binding; beta-tubulin binding; alpha-tubulin binding; actin binding;
Cellular component	integral component of membrane; plasma membrane; membrane; membrane raft; neuron projection; cell surface; integral component of plasma membrane; neuronal cell body membrane; presynaptic membrane;
Biological process	dopamine uptake involved in synaptic transmission; neurotransmitter transport; response to pain; monoamine transport; chemical synaptic transmission; norepinephrine transport; transmembrane transport; sodium ion transmembrane transport; norepinephrine uptake; neuron cellular homeostasis; neurotransmitter reuptake;
	Sources:Amigo / QuickGO
Orthologs
	6530
	20538
	ENSG00000103546
	ENSMUSG00000055368
	P23975
	O55192
	NM_001043; NM_001172501; NM_001172502; NM_001172504
	NM_009209
	NP_001034; NP_001165972; NP_001165973; NP_001165975
	NP_033235
	Wikidata
View/Edit Human	View/Edit Mouse

The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene.^[5]

NET is a monoamine transporter and is responsible for the sodium-chloride (Na⁺/Cl⁻)-dependent reuptake of extracellular norepinephrine (NE), which is also known as noradrenaline. NET can also reuptake extracellular dopamine (DA). The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft. NETs, along with the other monoamine transporters, are the targets of many antidepressants and recreational drugs. In addition, an overabundance of NET is associated with ADHD.^[6]^[7] There is evidence that single-nucleotide polymorphisms in the NET gene (SLC6A2) may be an underlying factor in some of these disorders.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103546 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055368 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pacholczyk T, Blakely RD, Amara SG (March 1991). "Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter". Nature. 350 (6316): 350–4. Bibcode:1991Natur.350..350P. doi:10.1038/350350a0. PMID 2008212. S2CID 4333895.
^ Cite error: The named reference Schroeter was invoked but never defined (see the help page).
^ ^a ^b Tellioglu T, Robertson D (November 2001). "Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications". Expert Reviews in Molecular Medicine. 2001 (29): 1–10. doi:10.1017/S1462399401003878. PMID 14987367. S2CID 30965333.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103546 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055368 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2008212-5] Pacholczyk T, Blakely RD, Amara SG (March 1991). "Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter". Nature. 350 (6316): 350–4. Bibcode:1991Natur.350..350P. doi:10.1038/350350a0. PMID 2008212. S2CID 4333895.

[Schroeter-6] Cite error: The named reference Schroeter was invoked but never defined (see the help page).

[pmid14987367-7] Tellioglu T, Robertson D (November 2001). "Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications". Expert Reviews in Molecular Medicine. 2001 (29): 1–10. doi:10.1017/S1462399401003878. PMID 14987367. S2CID 30965333.

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