The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1gene.[5][6]
Nuclear receptor 4A1 plays a key role in mediating inflammatory responses in macrophages.[9] In addition, subcellular localization of the NR4A1 protein appears to play a key role in the survival and death of cells.[10]
Expression is inducible by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[5]
^ abChang C, Kokontis J, Liao SS, Chang Y (1989). "Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily". Journal of Steroid Biochemistry. 34 (1–6): 391–395. doi:10.1016/0022-4731(89)90114-3. PMID2626032.