Nucleus reuniens

Nucleus reuniens
Details
Identifiers
Latinnucleus reuniens
NeuroNames309
NeuroLex IDbirnlex_770
TA98A14.1.08.632
FMA62153
Anatomical terms of neuroanatomy

The nucleus reuniens is a region of the thalamic midline nuclear group.[1][2] In the human brain, it is located in the interthalamic adhesion (massa intermedia).[3][4] It is also known as the medioventral nucleus.[5]

The nucleus reuniens receives afferent input from a large number of structures, mainly from limbic and limbic-associated structures.[6] It sends projections to the medial prefrontal cortex, the hippocampus, perirhinal cortex, and entorhinal cortex,[7][8][9] although there exist sparse connections to many other afferent structures as well.[10]

The unique medial prefrontal cortex and hippocampal connectivity allows reuniens to regulate neural traffic in this cortical network related to changes in an organism's attentiveness,[11] making reuniens critical to associative learning,[12] memory retrieval,[13] memory generalization,[14] spatial route planning,[15] and resilience to stress.[16]

  1. ^ Dolleman-van der Weel, Margriet J.; Griffin, Amy L.; Ito, Hiroshi T.; Shapiro, Matthew L.; Witter, Menno P.; Vertes, Robert P.; Allen, Timothy A. (2019). "The nucleus reuniens of the thalamus sits at the nexus of a hippocampus and medial prefrontal cortex circuit enabling memory and behavior". Learning & Memory. 26 (7): 191–205. doi:10.1101/lm.048389.118. ISSN 1549-5485. PMC 6581009. PMID 31209114.
  2. ^ Griffin, Amy L. (2015-01-01). "Role of the thalamic nucleus reuniens in mediating interactions between the hippocampus and medial prefrontal cortex during spatial working memory". Frontiers in Systems Neuroscience. 9: 29. doi:10.3389/fnsys.2015.00029. ISSN 1662-5137. PMC 4354269. PMID 25805977.
  3. ^ Carpenter, Malcolm; Sutin, Jerome (1983). Human Neuroanatomy. Baltimore: Williams & Wilkins. pp. 504–510. ISBN 978-0-683-01461-7.
  4. ^ Reeders, Puck C.; Rivera Núñez, M. Vanessa; Vertes, Robert P.; Mattfeld, Aaron T.; Allen, Timothy A. (2023-01-04). "Identifying the midline thalamus in humans in vivo". Brain Structure and Function. doi:10.1007/s00429-022-02607-6. ISSN 1863-2661. PMID 36598561.
  5. ^ Jones, Edward G (1985). The Thalamus. Springer. pp. 666–667. doi:10.1007/978-1-4615-1749-8. ISBN 978-1-4613-5704-9. S2CID 41337319.
  6. ^ McKenna, J. T.; Vertes, R. P. (2004). "Afferent projections to nucleus reuniens of the thalamus". The Journal of Comparative Neurology. 480 (2): 115–142. doi:10.1002/cne.20342. PMID 15514932. S2CID 9284778.
  7. ^ Wouterlood, F. G.; Saldana, E.; Witter, M. P. (1990). "Projection from the nucleus reuniens thalami to the hippocampal region: Light and electron microscopic tracing study in the rat with the anterograde tracerPhaseolus vulgaris-leucoagglutinin". The Journal of Comparative Neurology. 296 (2): 179–203. doi:10.1002/cne.902960202. PMID 2358531. S2CID 24568442.
  8. ^ Vertes, R. P. (2006). "Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat". Neuroscience. 142 (1): 1–20. doi:10.1016/j.neuroscience.2006.06.027. PMID 16887277. S2CID 5591335.
  9. ^ Viena, Tatiana D.; Rasch, Gabriela E.; Silva, Daniela; Allen, Timothy A. (2021). "Calretinin and calbindin architecture of the midline thalamus associated with prefrontal–hippocampal circuitry". Hippocampus. 31 (7): 770–789. doi:10.1002/hipo.23271. ISSN 1050-9631. PMC 8805340. PMID 33085824.
  10. ^ Herkenham, M. (1978). "The connections of the nucleus reuniens thalami: Evidence for a direct thalamo-hippocampal pathway in the rat". The Journal of Comparative Neurology. 177 (4): 589–610. doi:10.1002/cne.901770405. PMID 624792. S2CID 7535058.
  11. ^ Vertes, R. P.; Hoover, W. B.; Szigeti-Buck, K.; Leranth, C. (2007). "Nucleus reuniens of the midline thalamus: Link between the medial prefrontal cortex and the hippocampus". Brain Research Bulletin. 71 (6): 601–609. doi:10.1016/j.brainresbull.2006.12.002. PMC 4997812. PMID 17292803.
  12. ^ Eleore, L.; López-Ramos, J. C.; Guerra-Narbona, R.; Delgado-García, J. M. (2011). Izquierdo, Ivan (ed.). "Role of Reuniens Nucleus Projections to the Medial Prefrontal Cortex and to the Hippocampal Pyramidal CA1 Area in Associative Learning". PLOS ONE. 6 (8): e23538. Bibcode:2011PLoSO...623538E. doi:10.1371/journal.pone.0023538. PMC 3156136. PMID 21858159.
  13. ^ Jayachandran, Maanasa; Linley, Stephanie B.; Schlecht, Maximilian; Mahler, Stephen V.; Vertes, Robert P.; Allen, Timothy A. (2019). "Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events". Cell Reports. 28 (3): 640–654.e6. doi:10.1016/j.celrep.2019.06.053. PMC 6662648. PMID 31315044.
  14. ^ Xu, W.; Sudhof, T. C. (14 March 2013). "A Neural Circuit for Memory Specificity and Generalization". Science. 339 (6125): 1290–1295. Bibcode:2013Sci...339.1290X. doi:10.1126/science.1229534. PMC 3651700. PMID 23493706.
  15. ^ Ito, H. T.; Zhang, S. J.; Witter, M. P.; Moser, E. I.; Moser, M. B. (2015). "A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation". Nature. 522 (7554): 50–5. Bibcode:2015Natur.522...50I. doi:10.1038/nature14396. hdl:11250/2493579. PMID 26017312. S2CID 205243449.
  16. ^ Kafetzopoulos, V.; Kokras, N.; Sotiropoulos, I.; Oliveira, J. F.; Leite-Almeida, H.; Vasalou, A.; Sardinha, V. M.; Papadopoulou-Daifoti, Z.; Almeida, O. F. X. (2017-04-11). "The nucleus reuniens: a key node in the neurocircuitry of stress and depression". Molecular Psychiatry. 23 (3): 579–586. doi:10.1038/mp.2017.55. ISSN 1476-5578. PMC 5822458. PMID 28397837.