OLIG2

OLIG2
Identifiers
Aliases	OLIG2, BHLHB1, OLIGO2, PRKCBP2, RACK17, bHLHe19, oligodendrocyte lineage transcription factor 2, oligodendrocyte transcription factor 2
External IDs	OMIM: 606386; MGI: 1355331; HomoloGene: 4241; GeneCards: OLIG2; OMA:OLIG2 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 33,025,935 bp[1] End 33,029,196 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C3.3|16 52.6 cM Start 91,022,345 bp[2] End 91,025,565 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve globus pallidus internal globus pallidus amygdala ventral tegmental area subthalamic nucleus external globus pallidus substantia nigra C1 segment hippocampus proper Top expressed in lumbar subsegment of spinal cord medial ganglionic eminence optic nerve white matter of cerebellum deep cerebellar nuclei respiratory epithelium olfactory epithelium lateral geniculate nucleus anterior horn of spinal cord ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity protein homodimerization activity DNA-binding transcription factor activity HMG box domain binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process positive regulation of oligodendrocyte differentiation regulation of transcription, DNA-templated negative regulation of neuron differentiation thalamus development spinal cord oligodendrocyte cell fate specification oligodendrocyte differentiation negative regulation of transcription by RNA polymerase II transcription, DNA-templated nervous system development multicellular organism development oligodendrocyte cell fate specification neuron differentiation myelination neuron fate commitment spinal cord motor neuron differentiation spinal cord oligodendrocyte cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10215 50913 Ensembl ENSG00000205927 ENSMUSG00000039830 UniProt Q13516 Q9EQW6 RefSeq (mRNA) NM_005806 NM_016967 RefSeq (protein) NP_005797 NP_058663 Location (UCSC) Chr 21: 33.03 – 33.03 Mb Chr 16: 91.02 – 91.03 Mb PubMed search [3] [4]
Wikidata
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Oligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor encoded by the OLIG2 gene. The protein is of 329 amino acids in length, 32 kDa in size and contains one basic helix-loop-helix DNA-binding domain.^[5] It is one of the three members of the bHLH family. The other two members are OLIG1 and OLIG3. The expression of OLIG2 is mostly restricted in central nervous system, where it acts as both an anti-neurigenic and a neurigenic factor at different stages of development. OLIG2 is well known for determining motor neuron and oligodendrocyte differentiation, as well as its role in sustaining replication in early development. It is mainly involved in diseases such as brain tumor and Down syndrome.