OPCML

OPCML
Identifiers
Aliases	OPCML, IGLON1, OBCAM, OPCM, opioid binding protein/cell adhesion molecule-like, opioid binding protein/cell adhesion molecule like
External IDs	OMIM: 600632; MGI: 97397; HomoloGene: 55663; GeneCards: OPCML; OMA:OPCML - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	133,532,501 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	28,925,410 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; retinal pigment epithelium; ; orbitofrontal cortex; ; postcentral gyrus; ; superior frontal gyrus; ; Brodmann area 46; ; entorhinal cortex; ; Region I of hippocampus proper;
	Top expressed in
	primary motor cortex; ; lateral septal nucleus; ; ventromedial nucleus; ; cingulate gyrus; ; subiculum; ; piriform cortex; ; lateral geniculate nucleus; ; anterior amygdaloid area; ; prefrontal cortex; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	anchored component of membrane; plasma membrane; membrane; extracellular region;
Biological process	neuron recognition; cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	4978
	330908
	ENSG00000183715
	ENSMUSG00000062257
	Q14982
	n/a
NM_001012393; NM_002545; NM_001319103; NM_001319104; NM_001319105;
	NM_001319106
	NM_177906
NP_001012393; NP_001306032; NP_001306033; NP_001306034; NP_001306035;
	NP_002536; NP_002536.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.^[5]^[6]

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the cell membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183715 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062257 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics. 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID 8244387.
^ ^a ^b "Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183715 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062257 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8244387-5] Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics. 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID 8244387.

[entrez-6] "Entrez Gene: OPCML opioid binding protein/cell adhesion molecule-like".

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