OPN5

OPN5
Identifiers
Aliases	OPN5, GPR136, GRP136, PGR12, TMEM13, opsin 5
External IDs	OMIM: 609042; MGI: 2662912; HomoloGene: 72341; GeneCards: OPN5; OMA:OPN5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	47,832,780 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	42,922,286 bp
RNA expression pattern
	Top expressed in
	testicle; ; left testis; ; right testis; ; gonad; ; skin of thigh; ; left ventricle; ; lower lobe of lung; ; Brodmann area 9; ; prefrontal cortex; ; apex of heart;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	11-cis retinal binding; G protein-coupled receptor activity; photoreceptor activity; signal transducer activity; G protein-coupled photoreceptor activity;
Cellular component	integral component of membrane; membrane; photoreceptor outer segment; integral component of plasma membrane;
Biological process	signal transduction; visual perception; response to stimulus; G protein-coupled receptor signaling pathway; phototransduction; detection of visible light; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	221391
	353344
	ENSG00000124818
	ENSMUSG00000043972
	Q6U736
	Q6VZZ7
	NM_001030051; NM_181744
	NM_181753
	NP_859528
	NP_861418
	Wikidata
View/Edit Human	View/Edit Mouse

Opsin-5, also known as G-protein coupled receptor 136 or neuropsin is a protein that in humans is encoded by the OPN5 gene. Opsin-5 is a member of the opsin subfamily of the G protein-coupled receptors.^[5]^[6]^[7] It is a photoreceptor protein sensitive to ultraviolet (UV) light. The OPN5 gene was discovered in mouse and human genomes and its mRNA expression was also found in neural tissues. Neuropsin is bistable at 0 °C and activates a UV-sensitive, heterotrimeric G protein Gi-mediated pathway in mammalian and avian tissues.^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124818 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043972 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tarttelin EE, Bellingham J, Hankins MW, Foster RG, Lucas RJ (Nov 2003). "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue". FEBS Letters. 554 (3): 410–6. doi:10.1016/S0014-5793(03)01212-2. PMID 14623103. S2CID 9577067.
^ Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Letters. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. S2CID 11563502.
^ "Entrez Gene: OPN5 opsin 5".
^ Kojima D, Mori S, Torii M, Wada A, Morishita R, Fukada Y (2011). "UV-sensitive photoreceptor protein OPN5 in humans and mice". PLOS ONE. 6 (10): e26388. Bibcode:2011PLoSO...626388K. doi:10.1371/journal.pone.0026388. PMC 3197025. PMID 22043319.
^ Yamashita T, Ohuchi H, Tomonari S, Ikeda K, Sakai K, Shichida Y (December 2010). "Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein". Proceedings of the National Academy of Sciences of the United States of America. 107 (51): 22084–22089. Bibcode:2010PNAS..10722084Y. doi:10.1073/pnas.1012498107. PMC 3009823. PMID 21135214.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124818 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043972 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Tarttelin_2003-5] Tarttelin EE, Bellingham J, Hankins MW, Foster RG, Lucas RJ (Nov 2003). "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue". FEBS Letters. 554 (3): 410–6. doi:10.1016/S0014-5793(03)01212-2. PMID 14623103. S2CID 9577067.

[Fredriksson_2003-6] Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Letters. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. S2CID 11563502.

[entrez-7] "Entrez Gene: OPN5 opsin 5".

[Kojima_2011-8] Kojima D, Mori S, Torii M, Wada A, Morishita R, Fukada Y (2011). "UV-sensitive photoreceptor protein OPN5 in humans and mice". PLOS ONE. 6 (10): e26388. Bibcode:2011PLoSO...626388K. doi:10.1371/journal.pone.0026388. PMC 3197025. PMID 22043319.

[Yamashita_2010-9] Yamashita T, Ohuchi H, Tomonari S, Ikeda K, Sakai K, Shichida Y (December 2010). "Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein". Proceedings of the National Academy of Sciences of the United States of America. 107 (51): 22084–22089. Bibcode:2010PNAS..10722084Y. doi:10.1073/pnas.1012498107. PMC 3009823. PMID 21135214.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]