ORAI1

ORAI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MAK, 4EHQ
Identifiers
Aliases	ORAI1, CRACM1, IMD9, ORAT1, TAM2, TMEM142A, ORAI calcium release-activated calcium modulator 1
External IDs	OMIM: 610277; MGI: 1925542; HomoloGene: 13117; GeneCards: ORAI1; OMA:ORAI1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	121,642,677 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	123,168,519 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; muscle of thigh; ; skin of leg; ; skin of abdomen; ; gastrocnemius muscle; ; monocyte; ; blood; ; spleen; ; olfactory zone of nasal mucosa; ; gonad;
	Top expressed in
	granulocyte; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; tibiofemoral joint; ; extraocular muscle; ; zygote; ; digastric muscle; ; muscle of thigh; ; primary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	store-operated calcium channel activity; calcium channel activity; calmodulin binding; protein binding; identical protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane;
Biological process	regulation of calcium ion transport; adaptive immune response; immune system process; ion transport; calcium ion transmembrane transport; calcium ion transport; positive regulation of calcium ion transport; store-operated calcium entry; transport;
	Sources:Amigo / QuickGO
Orthologs
	84876
	109305
	ENSG00000276045
	ENSMUSG00000049686
	Q96D31
	Q8BWG9
	NM_032790
	NM_175423
	NP_116179
	NP_780632
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene.^[5]^[6]^[7] Orai channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans^[5] The mammalian orai family has two additional homologs, Orai2 and Orai3. Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form hexamers.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000276045 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049686 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". Nature. 441 (7090): 179–85. Bibcode:2006Natur.441..179F. doi:10.1038/nature04702. PMID 16582901. S2CID 1605392.
^ Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP (May 2006). "CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry". Science. 312 (5777): 1220–3. Bibcode:2006Sci...312.1220V. doi:10.1126/science.1127883. PMC 5685805. PMID 16645049.
^ Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD (June 2006). "Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity". Proceedings of the National Academy of Sciences of the United States of America. 103 (24): 9357–62. doi:10.1073/pnas.0603161103. PMC 1482614. PMID 16751269.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000276045 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049686 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16582901-5] Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". Nature. 441 (7090): 179–85. Bibcode:2006Natur.441..179F. doi:10.1038/nature04702. PMID 16582901. S2CID 1605392.

[pmid16645049-6] Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP (May 2006). "CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry". Science. 312 (5777): 1220–3. Bibcode:2006Sci...312.1220V. doi:10.1126/science.1127883. PMC 5685805. PMID 16645049.

[pmid16751269-7] Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD (June 2006). "Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity". Proceedings of the National Academy of Sciences of the United States of America. 103 (24): 9357–62. doi:10.1073/pnas.0603161103. PMC 1482614. PMID 16751269.

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