ORC1

ORC1
Identifiers
Aliases	ORC1, HSORC1L, PARC1, origin recognition complex subunit 1
External IDs	OMIM: 601902; MGI: 1328337; HomoloGene: 31221; GeneCards: ORC1; OMA:ORC1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	52,404,423 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	108,472,030 bp
RNA expression pattern
	Top expressed in
	testicle; ; ventricular zone; ; gonad; ; ganglionic eminence; ; bone marrow; ; mucosa of transverse colon; ; secondary oocyte; ; rectum; ; stromal cell of endometrium; ; bone marrow cells;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; epiblast; ; tail of embryo; ; genital tubercle; ; primitive streak; ; embryo; ; embryo; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; chromatin binding; protein binding; ATP binding; DNA replication origin binding; metal ion binding;
Cellular component	nuclear origin of replication recognition complex; plasma membrane; nucleolus; origin recognition complex; nucleus; nucleoplasm; cytosol;
Biological process	G1 phase; DNA replication; regulation of transcription involved in G1/S transition of mitotic cell cycle; DNA replication initiation; G1/S transition of mitotic cell cycle; mitotic cell cycle; mitotic DNA replication checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	4998
	18392
	ENSG00000085840
	ENSMUSG00000028587
	Q13415
	Q9Z1N2
	NM_001190818; NM_001190819; NM_004153
	NM_001014425; NM_011015
	NP_001177747; NP_001177748; NP_004144
	NP_035145
	Wikidata
View/Edit Human	View/Edit Mouse

Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene.^[5]^[6] It is closely related to CDC6, and both are the same protein in archaea.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000085840 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028587 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eki T, Okumura K, Amin A, Ishiai M, Abe M, Nogami M, Taguchi H, Hurwitz J, Murakami Y, Hanaoka F (Sep 1996). "Mapping of the human homologue (ORC1L) of the yeast origin recognition complex subunit 1 gene to chromosome band 1p32". Genomics. 36 (3): 559–61. doi:10.1006/geno.1996.0511. PMID 8884289.
^ "Entrez Gene: ORC1L origin recognition complex, subunit 1-like (yeast)".
^ Ausiannikava, Darya; Allers, Thorsten (31 January 2017). "Diversity of DNA Replication in the Archaea". Genes. 8 (2): 56. doi:10.3390/genes8020056. PMC 5333045. PMID 28146124.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000085840 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028587 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8884289-5] Eki T, Okumura K, Amin A, Ishiai M, Abe M, Nogami M, Taguchi H, Hurwitz J, Murakami Y, Hanaoka F (Sep 1996). "Mapping of the human homologue (ORC1L) of the yeast origin recognition complex subunit 1 gene to chromosome band 1p32". Genomics. 36 (3): 559–61. doi:10.1006/geno.1996.0511. PMID 8884289.

[entrez-6] "Entrez Gene: ORC1L origin recognition complex, subunit 1-like (yeast)".

[pmid28146124-7] Ausiannikava, Darya; Allers, Thorsten (31 January 2017). "Diversity of DNA Replication in the Archaea". Genes. 8 (2): 56. doi:10.3390/genes8020056. PMC 5333045. PMID 28146124.

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