OTUB1

OTUB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZFY, 3VON, 4DDG, 4DDI, 4DHZ, 4I6L, 4LDT
Identifiers
Aliases	OTUB1, OTB1, OTU1, HSPC263, OTU deubiquitinase, ubiquitin aldehyde binding 1
External IDs	OMIM: 608337; MGI: 2147616; HomoloGene: 134542; GeneCards: OTUB1; OMA:OTUB1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,001,811 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	7,183,681 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; right hemisphere of cerebellum; ; Brodmann area 10; ; cingulate gyrus; ; anterior cingulate cortex; ; granulocyte; ; pancreatic ductal cell; ; mucosa of ileum; ; Brodmann area 9;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; yolk sac; ; ventricular zone; ; neural layer of retina; ; morula; ; tail of embryo; ; lip; ; primary visual cortex; ; spermatocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; NEDD8-specific protease activity; thiol-dependent deubiquitinase; peptidase activity; ubiquitin binding; protein binding; hydrolase activity; ubiquitin protein ligase binding;
Cellular component	cytoplasm; extracellular exosome; nucleus; nucleoplasm; cytosol;
Biological process	adaptive immune response; protein K48-linked deubiquitination; immune system process; proteolysis; cellular response to DNA damage stimulus; negative regulation of double-strand break repair; negative regulation of histone H2A K63-linked ubiquitination; cellular response to interleukin-1; DNA repair; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	55611
	107260
	ENSG00000167770
	ENSMUSG00000024767
	Q96FW1
	Q7TQI3
	NM_017670
	NM_134150
	NP_060140
	NP_598911
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin thioesterase OTUB1 also known as otubain-1 is an enzyme that in humans is encoded by the OTUB1 gene.^[5]^[6] Alternative splicing results in multiple transcript variants.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167770 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024767 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.
^ "Entrez Gene: OTUB1 OTU domain, ubiquitin aldehyde binding 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167770 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024767 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12704427-5] Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.

[entrez-6] "Entrez Gene: OTUB1 OTU domain, ubiquitin aldehyde binding 1".

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