OTUB2

OTUB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TFF, 4FJV
Identifiers
Aliases	OTUB2, C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2
External IDs	OMIM: 608338; MGI: 1915399; HomoloGene: 57056; GeneCards: OTUB2; OMA:OTUB2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	94,048,930 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	103,372,609 bp
RNA expression pattern
	Top expressed in
	testicle; ; left testis; ; right testis; ; skin of leg; ; ventricular zone; ; gonad; ; skin of abdomen; ; ganglionic eminence; ; placenta; ; islet of Langerhans;
	Top expressed in
	seminiferous tubule; ; spermatid; ; esophagus; ; primary oocyte; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; zygote; ; Region I of hippocampus proper; ; lacrimal gland; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiol-dependent deubiquitinase; peptidase activity; cysteine-type peptidase activity; NEDD8-specific protease activity; ubiquitin binding; protein binding; hydrolase activity;
Cellular component	nucleus;
Biological process	protein deubiquitination; protein K63-linked deubiquitination; protein K48-linked deubiquitination; proteolysis; protein K11-linked deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	78990
	68149
	ENSG00000089723; ENSG00000277276
	ENSMUSG00000021203
	Q96DC9
	Q9CQX0
	NM_023112
	NM_001177841; NM_026580
	NP_075601
	NP_001171312; NP_080856
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.^[5]^[6]

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.^[6]

^ ^a ^b ^c ENSG00000277276 GRCh38: Ensembl release 89: ENSG00000089723, ENSG00000277276 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021203 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.
^ ^a ^b "Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2".

[refGRCh38Ensembl-1] ENSG00000277276 GRCh38: Ensembl release 89: ENSG00000089723, ENSG00000277276 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021203 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12704427-5] Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.

[entrez-6] "Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2".

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