OTUD7B

OTUD7B
Identifiers
Aliases	OTUD7B, CEZANNE, ZA20D1, OTU deubiquitinase 7B
External IDs	OMIM: 611748; MGI: 2654703; HomoloGene: 10624; GeneCards: OTUD7B; OMA:OTUD7B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,010,726 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,068,446 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; internal globus pallidus; ; sural nerve; ; secondary oocyte; ; tendon of biceps brachii; ; corpus callosum; ; inferior ganglion of vagus nerve; ; C1 segment; ; Skeletal muscle tissue of biceps brachii; ; epithelium of colon;
	Top expressed in
	blood; ; retinal pigment epithelium; ; sciatic nerve; ; right lung lobe; ; neural layer of retina; ; spermatid; ; lumbar subsegment of spinal cord; ; spermatocyte; ; triceps brachii muscle; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; cysteine-type peptidase activity; zinc ion binding; metal ion binding; peptidase activity; K63-linked polyubiquitin modification-dependent protein binding; protein binding; thiol-dependent deubiquitinase; hydrolase activity; Lys48-specific deubiquitinase activity;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	mucosal immune response; negative regulation of protein localization to nucleus; protein K48-linked deubiquitination; protein deubiquitination involved in ubiquitin-dependent protein catabolic process; immune system process; negative regulation of transcription by RNA polymerase II; negative regulation of I-kappaB kinase/NF-kappaB signaling; proteolysis; negative regulation of interleukin-8 production; protein K63-linked deubiquitination; immune response; protein deubiquitination; protein K11-linked deubiquitination; adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	56957
	229603
	ENSG00000264522
	ENSMUSG00000038495
	Q6GQQ9
	B2RUR8
	NM_020205
	NM_001025613; NM_001025614
	NP_064590
	NP_001020784; NP_001020785
	Wikidata
View/Edit Human	View/Edit Mouse

OTU domain-containing protein 7B is a protein that in humans is encoded by the OTUD7B gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000264522 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038495 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Biochemical Journal. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.
^ "Entrez Gene: OTUD7B OTU domain containing 7B".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000264522 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038495 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11463333-5] Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Biochemical Journal. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.

[entrez-6] "Entrez Gene: OTUD7B OTU domain containing 7B".

[1]

[2]

[3]

[4]

[5]

[6]