Ogataea polymorpha

Ogataea polymorpha
Scientific classification
Kingdom:
Fungi
Division:
Ascomycota
Class:
Saccharomycetes
Order:
Saccharomycetales
Family:
Saccharomycetaceae
Genus:
Ogataea
Species:
O. polymorpha
Binomial name
Ogataea polymorpha
(Morais & M.H.Maia) Y.Yamada, K.Maeda & Mikata
Synonyms [1]
  • Candida thermophila K.S.Shin, Y.K.Shin, J.H.Yoon & Y.H.Park
  • Hansenula angusta Wick.
  • Hansenula polymorpha Morais & M.H.Maia
  • Ogataea thermophila G. Péter, Tornai-Leh., K.S.Shin & Dlauchy
  • Torulopsis methanothermo Urakami

Ogataea polymorpha is a methylotrophic yeast with unusual characteristics. It is used as a protein factory for pharmaceuticals.

Fig. 1. (A) Micrograph of a budding O. polymorpha cell, grown in a chemostat under methanol conditions. The cytosol is crowded by peroxisomes (after Gellissen et al. 2005).
(B) Methanol metabolism pathway in O. polymorpha (modified after Gellissen et al. 2005). 1 - alcohol oxidase, 2 – catalase, 3 – dihydroxyacetone synthase, 4 – formaldehyde dehydrogenase, 5 – formate dehydrogenase, 6 – dihydroxyacetone kinase, 7 – GSH – glutathione, Xu5P – xylulose-5-phosphate, FBP – fructose-1,6-bisphosphate.

Ogataea polymorpha belongs to a limited number of methylotrophic yeast species – yeasts that can grow on methanol. The range of methylotrophic yeasts includes Candida boidinii, Pichia methanolica, Pichia pastoris and Ogataea polymorpha. O. polymorpha is taxonomically a species of the family Saccharomycetaceae.

  1. ^ "Ogataea polymorpha (Morais & M.H. Maia) Y. Yamada, K. Maeda & Mikata, Biosc., Biotechn., Biochem. 58(7): 1254 (1994)". Index Fungorum. Retrieved June 27, 2011.