Ohio State Route 221

State Route 221
Route information
Maintained by ODOT
Length	8.04 mi[1] (12.94 km)
Existed	1924–present
Major junctions
South end	US 52 in Higginsport
North end	SR 125 in Georgetown
Location
Country	United States
State	Ohio
Counties	Brown
Highway system
Ohio State Highway System Interstate US State Scenic
← SR 220 → SR 222

State Route 221 (SR 221, OH 221) is a north–south state highway in southwestern Ohio, a U.S. state. Situated entirely in the southern portion of Brown County, the southern terminus of State Route 221 is at U.S. Route 52 in the eastern end of Higginsport, a village set along the banks of the Ohio River. The northern terminus of State Route 221 is at State Route 125 in the western portion of Georgetown, the county seat of Brown County.