State highway in Medina County, Ohio, US
State Route 421 (SR 421) is a two-lane east-west state highway in the north-central portion of Ohio. Existing entirely within Medina County, SR 421's endpoints are at opposite ends of the concurrency of U.S. Route 42 (US 42) and US 224, which together form the four-lane bypass of Lodi. SR 421 serves both as a de facto business route for US 42 and US 224 for Lodi, as well as a connector between the two U.S. routes and SR 83, which SR 421 intersects in downtown Lodi.