Oliceridine

Oliceridine
Clinical data
Pronunciation	OH li SER i deen
Trade names	Olinvyk
Other names	TRV-130, TRV130
AHFS/Drugs.com	Professional Drug Facts
License data	US DailyMed: Oliceridine;
Routes of; administration	Intravenous
ATC code	N02AX07 (WHO) ;
Legal status
Legal status	US: WARNINGSchedule II;
Identifiers
	IUPAC name N-[(3-Methoxythiophen-2-yl)methyl]-2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethanamine;
CAS Number	1401028-24-7;
PubChem CID	66553195;
DrugBank	DB14881;
ChemSpider	30841043;
UNII	MCN858TCP0;
KEGG	D11214;
ChEMBL	ChEMBL2443262;
PDB ligand	WH2 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID201031292 ;
Chemical and physical data
Formula	C22H30N2O2S
Molar mass	386.55 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc1ccsc1CNCC[C@]2(CCOC3(CCCC3)C2)c4ccccn4;
	InChI InChI=1S/C22H30N2O2S/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3/t21-/m1/s1; Key:DMNOVGJWPASQDL-OAQYLSRUSA-N;

Oliceridine, sold under the brand name Olinvyk, is an opioid medication that is used for the treatment of moderate to severe acute pain in adults.^[3] It is given by intravenous (IV) injection.^[3]

The most common side effects include nausea, vomiting, dizziness, headache, constipation, itchy skin and low oxygen levels in blood.^[4]

It was approved for medical use in the United States in August 2020.^[4]

^ "Olinvyk- oliceridine injection, solution". DailyMed. 18 August 2020. Retrieved 16 September 2020.
^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ ^a ^b "FDA Approves New Opioid for Intravenous Use in Hospitals, Other Controlled Clinical Settings". U.S. Food and Drug Administration (FDA) (Press release). 7 August 2020. Retrieved 7 August 2020. This article incorporates text from this source, which is in the public domain.
^ ^a ^b "Drug Trials Snapshots: Olinvyk". U.S. Food and Drug Administration (FDA). 7 August 2020. Retrieved 16 September 2020. This article incorporates text from this source, which is in the public domain.

[1] "Olinvyk- oliceridine injection, solution". DailyMed. 18 August 2020. Retrieved 16 September 2020.

[FDA-AllBoxedWarnings-2] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[FDA_PR-3] "FDA Approves New Opioid for Intravenous Use in Hospitals, Other Controlled Clinical Settings". U.S. Food and Drug Administration (FDA) (Press release). 7 August 2020. Retrieved 7 August 2020. This article incorporates text from this source, which is in the public domain.

[FDA_snapshot-4] "Drug Trials Snapshots: Olinvyk". U.S. Food and Drug Administration (FDA). 7 August 2020. Retrieved 16 September 2020. This article incorporates text from this source, which is in the public domain.

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