Osteonectin

SPARC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BMO, 1NUB, 1SRA, 2V53
Identifiers
Aliases	SPARC, BM-40, ON, OI17, secreted protein acidic and cysteine rich, ONT
External IDs	OMIM: 182120; MGI: 98373; HomoloGene: 31132; GeneCards: SPARC; OMA:SPARC - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 151,661,096 bp[1] End 151,686,975 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 33.04 cM Start 55,285,326 bp[2] End 55,314,009 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia stromal cell of endometrium periodontal fiber gallbladder trigeminal ganglion olfactory bulb spinal ganglia visceral pleura Descending thoracic aorta smooth muscle tissue Top expressed in calvaria body of femur ascending aorta aortic valve tibiofemoral joint umbilical cord stroma of bone marrow efferent ductule carotid body gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding protein binding extracellular matrix binding collagen binding extracellular matrix structural constituent Cellular component cytoplasm platelet alpha granule endocytic vesicle lumen nuclear matrix plasma membrane intracellular anatomical structure basement membrane cell surface platelet alpha granule membrane mitochondrion platelet alpha granule lumen nucleus extracellular space vesicle extracellular region extracellular matrix synapse collagen-containing extracellular matrix glutamatergic synapse Biological process response to cytokine response to cadmium ion ossification lung development cellular response to growth factor stimulus response to peptide hormone platelet degranulation extracellular matrix organization response to L-ascorbic acid response to glucocorticoid wound healing receptor-mediated endocytosis negative regulation of endothelial cell proliferation positive regulation of endothelial cell migration response to calcium ion response to gravity heart development response to lipopolysaccharide response to lead ion regulation of cell population proliferation negative regulation of angiogenesis inner ear development regulation of cell morphogenesis response to cAMP response to ethanol bone development signal transduction pigmentation regulation of synapse organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6678 20692 Ensembl ENSG00000113140 ENSMUSG00000018593 UniProt P09486 P07214 RefSeq (mRNA) NM_003118 NM_001309443 NM_001309444 NM_009242 NM_001290817 RefSeq (protein) NP_001296372 NP_001296373 NP_003109 NP_001277746 NP_033268 Location (UCSC) Chr 5: 151.66 – 151.69 Mb Chr 11: 55.29 – 55.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene.

Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. A correlation between osteonectin over-expression and ampullary cancers and chronic pancreatitis has been found.