Oxybutynin

Oxybutynin
Clinical data
Trade namesDitropan, Gelnique, others
AHFS/Drugs.comMonograph
MedlinePlusa682141
License data
Pregnancy
category
  • AU: B1
Routes of
administration		By mouth, transdermal
Drug classAntimuscarinic
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding91–93%
MetabolitesN-Desethyloxybutynin
Elimination half-life12.4–13.2 hours
Identifiers
  • 4-Diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylethanoate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.158.590 Edit this at Wikidata
Chemical and physical data
FormulaC22H31NO3
Molar mass357.494 g·mol−1
3D model (JSmol)
  • O=C(OCC#CCN(CC)CC)C(O)(c1ccccc1)C2CCCCC2
  • InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3 checkY
  • Key:XIQVNETUBQGFHX-UHFFFAOYSA-N checkY
  (verify)

Oxybutynin, sold under the brand name Ditropan among others, is an anticholinergic medication primarily used to treat overactive bladder. It is widely considered a first-line therapy for overactive bladder due to its well-studied side effect profile, broad applicability, and continued efficacy over long periods of time. It works similar to tolterodine, darifenacin, and solifenacin, although it is usually preferred over these medications. It is sometimes used off-label for treatment of hyperhidrosis, or excessive sweating. It has also been used off-label to treat bedwetting in children, but this use has declined, as it is most likely ineffective in this role. It is taken by mouth or applied to the skin.

Common side effects include dry mouth, constipation, dizziness, trouble sleeping, and urinary tract infections.[6] Serious side effects may include urinary retention and an increased risk of heat stroke.[6] Use in pregnancy appears safe but has not been well studied while use in breastfeeding is of unclear safety.[7] It is an antimuscarinic and works by blocking the effects of acetylcholine on smooth muscle.[6]

Oxybutynin was approved for medical use in the US in 1975.[6] It is available as a generic medication.[8] In 2022, it was the 110th most commonly prescribed medication in the United States, with more than 5 million prescriptions.[9][10]

  1. ^ "Ditropan XL (oxybutynin chloride) Extended Release Tablets for oral use Initial U.S. Approval: 1975". DailyMed. Retrieved June 17, 2024.
  2. ^ "Gelnique- oxybutynin chloride gel". DailyMed. March 1, 2019. Retrieved June 17, 2024.
  3. ^ "Oxytrol- oxybutynin patch". DailyMed. May 29, 2024. Retrieved June 17, 2024.
  4. ^ "Oxytrol for Women- oxybutynin patch". DailyMed. August 13, 2016. Retrieved June 17, 2024.
  5. ^ "Kentera EPAR". European Medicines Agency (EMA). June 15, 2004. Retrieved October 12, 2024.
  6. ^ a b c d "Oxybutynin Chloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved March 3, 2019.
  7. ^ "Oxybutynin Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved March 3, 2019.
  8. ^ British National Formulary: BNF 76 (76th ed.). Pharmaceutical Press. 2018. ISBN 978-0-85711-338-2.
  9. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on August 30, 2024. Retrieved August 30, 2024.
  10. ^ "Oxybutynin Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved August 30, 2024.