Oxyfedrine

Not to be confused with Oxilofrine.
Oxyfedrine
Clinical data
Trade namesIldamen, Modacor, Myofedrin
Other namesOxyfedrin; Oxyphedrine; Oxyphedrin; Oxifedrine; Oxifedrin; Oxiphedrine; Oxiphedrin
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, intravenous[1]
Drug classSympathomimetic; Coronary vasodilator; β-Adrenergic receptor partial agonist; Norepinephrine releasing agent
ATC code
Pharmacokinetic data
BioavailabilityOral: 85%[1]
Protein bindingAlmost 100%[1]
Metabolites• Norephedrine[2]
Elimination half-life4.2 hours[1]
ExcretionUrine (active metabolites 90%)[1]
Identifiers
  • (RS)-3-[(2-Hydroxy-1-methyl-2-phenylethyl)amino]-1-(3-methoxyphenyl)propan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H23NO3
Molar mass313.397 g·mol−1
3D model (JSmol)
  • C[C@@H]([C@@H](c1ccccc1)O)NCCC(=O)c2cccc(c2)OC
  • InChI=1S/C19H23NO3/c1-14(19(22)15-7-4-3-5-8-15)20-12-11-18(21)16-9-6-10-17(13-16)23-2/h3-10,13-14,19-20,22H,11-12H2,1-2H3/t14-,19-/m0/s1
  • Key:GDYUVHBMFVMBAF-LIRRHRJNSA-N
  (verify)

Oxyfedrine, sold under the brand names Ildamen and Myofedrin among others, is a sympathomimetic agent and coronary vasodilator which is used in the treatment of coronary heart disease, angina pectoris, and acute myocardial infarction.[1][3][4][5][6][7] It is taken by mouth or intravenously.[1]

The drug acts as a β-adrenergic receptor partial agonist.[1][7] It may also act as a norepinephrine releasing agent via its major active metabolite norephedrine.[2] Oxyfedrine is a phenethylamine and amphetamine derivative.[6][7]

Oxyfedrine has been marketed in Europe, Hong Kong, India, Central America, and elsewhere.[4][8][9] It appears to remain marketed only in India.[9]

  1. ^ a b c d e f g h Kirsten R, Nelson K, Kirsten D, Heintz B (July 1998). "Clinical pharmacokinetics of vasodilators. Part II". Clin Pharmacokinet. 35 (1): 9–36. doi:10.2165/00003088-199835010-00002. PMID 9673832.
  2. ^ a b Cite error: The named reference AppelPlanzPalm1975 was invoked but never defined (see the help page).
  3. ^ Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 923. ISBN 978-1-4757-2085-3. Retrieved 29 August 2024.
  4. ^ a b Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Index nominum. Medpharm Scientific Publishers. p. 777. ISBN 978-3-88763-075-1. Retrieved 29 August 2024.
  5. ^ Morton IK, Hall JM (2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 212. ISBN 978-94-011-4439-1. Retrieved 2024-08-29.
  6. ^ a b "Oxyfedrine: Uses, Interactions, Mechanism of Action". DrugBank Online. 23 June 2017. Retrieved 29 August 2024.
  7. ^ a b c Cite error: The named reference BeckettFoster1972 was invoked but never defined (see the help page).
  8. ^ https://web.archive.org/web/20121020185501/https://www.drugs.com/international/oxyfedrine.html
  9. ^ a b https://web.archive.org/web/20210106003945/https://www.drugs.com/international/oxyfedrine.html