Oyugis is the second-largest town (after Homa Bay town) in Homa Bay County in Nyanza Kenya. The town lies along the Kisumu-Kisii highway. It is the commercial and financial centre of Rachuonyo Sub-County in Homa Bay County of the former Nyanza Province.
Though small in comparison to neighbouring Kisii, Oyugis has recently registered fast growth especially since the creation of the district and increased use of the town by NGOs operating in the area and the Sondu Miriu hydroelectric power station.