Ozanimod

Ozanimod
Clinical data
Trade namesZeposia
Other namesRPC-1063
AHFS/Drugs.comMonograph
MedlinePlusa620029
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life19 hours
Identifiers
  • 5-(3-{(1S)-1-[(2-Hydroxyethyl)amino]-2,3-dihydro-1H-inden-4-yl}-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.247.081 Edit this at Wikidata
Chemical and physical data
FormulaC23H24N4O3
Molar mass404.470 g·mol−1
3D model (JSmol)
  • CC(C)Oc1ccc(cc1C#N)c2nc(no2)c3cccc4c3CC[C@@H]4NCCO
  • InChI=1S/C23H24N4O3/c1-14(2)29-21-9-6-15(12-16(21)13-24)23-26-22(27-30-23)19-5-3-4-18-17(19)7-8-20(18)25-10-11-28/h3-6,9,12,14,20,25,28H,7-8,10-11H2,1-2H3/t20-/m0/s1
  • Key:XRVDGNKRPOAQTN-FQEVSTJZSA-N

Ozanimod, sold under the brand name Zeposia, is an immunomodulatory medication for the treatment of relapsing multiple sclerosis and ulcerative colitis.[3][4][6][7] It acts as a sphingosine-1-phosphate receptor (S1PR) agonist, sequestering lymphocytes to peripheral lymphoid organs and away from their sites of chronic inflammation.[6]

The most common adverse reactions are upper respiratory infection, hepatic transaminase elevation, orthostatic hypotension, urinary tract infection, back pain, and hypertension.[3][8]

Ozanimod was approved for medical use in the United States in March 2020,[8][9][10] in the European Union in May 2020,[4] and in Australia in July 2020.[1][11]

  1. ^ a b c "Zeposia Australian Prescription Medicine Decision Summary". Therapeutic Goods Administration (TGA). July 27, 2020. Retrieved August 16, 2020.
  2. ^ "Summary Basis of Decision (SBD) for Zeposia". Health Canada. October 23, 2014. Retrieved May 29, 2022.
  3. ^ a b c "Zeposia- ozanimod hydrochloride capsule Zeposia 7-Day Starter Pack- ozanimod hydrochloride kit Zeposia Starter Kit- ozanimod hydrochloride kit". DailyMed. November 16, 2022. Retrieved December 30, 2022.
  4. ^ a b c "Zeposia EPAR". European Medicines Agency. March 26, 2020. Retrieved August 17, 2020.
  5. ^ "Zeposia Product information". Union Register of medicinal products. Retrieved March 3, 2023.
  6. ^ a b Scott FL, Clemons B, Brooks J, Brahmachary E, Powell R, Dedman H, et al. (June 2016). "Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune disease-modifying activity". British Journal of Pharmacology. 173 (11): 1778–92. doi:10.1111/bph.13476. PMC 4867749. PMID 26990079.
  7. ^ Cite error: The named reference BMS PR 20210527 was invoked but never defined (see the help page).
  8. ^ a b "U.S. Food and Drug Administration Approves Bristol Myers Squibb's Zeposia (ozanimod), a New Oral Treatment for Relapsing Forms of Multiple Sclerosis". Bristol-Myers Squibb Company (Press release). March 26, 2020. Retrieved March 26, 2020.
  9. ^ "Drug Trials Snapshots: Zeposia". U.S. Food and Drug Administration (FDA). March 25, 2020. Retrieved April 1, 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  10. ^ "Drug Approval Package: Zeposia". U.S. Food and Drug Administration (FDA). April 23, 2020. Retrieved October 3, 2020.
  11. ^ Cite error: The named reference Ozanimod hydrochloride AusPAR was invoked but never defined (see the help page).