P2RY2

P2RY2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z8E
Identifiers
Aliases	P2RY2, HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R, purinergic receptor P2Y2
External IDs	OMIM: 600041; MGI: 105107; HomoloGene: 1927; GeneCards: P2RY2; OMA:P2RY2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	73,242,427 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	100,662,073 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; Skeletal muscle tissue of rectus abdominis; ; mucosa of esophagus; ; vastus lateralis muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; gingival epithelium; ; triceps brachii muscle;
	Top expressed in
	muscle of thigh; ; extensor digitorum longus muscle; ; corneal stroma; ; plantaris muscle; ; granulocyte; ; soleus muscle; ; interventricular septum; ; skeletal muscle tissue; ; digastric muscle; ; thoracic diaphragm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; G protein-coupled purinergic nucleotide receptor activity; signal transducer activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane;
Biological process	G protein-coupled purinergic nucleotide receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; cellular ion homeostasis; positive regulation of mucus secretion; signal transduction; blood vessel diameter maintenance; G protein-coupled receptor signaling pathway; cellular response to ATP;
	Sources:Amigo / QuickGO
Orthologs
	5029
	18442
	ENSG00000175591
	ENSMUSG00000032860
	P41231
	P35383
	NM_002564; NM_176071; NM_176072
	NM_008773; NM_001302346; NM_001302347
	NP_002555; NP_788085; NP_788086
	NP_001289275; NP_001289276; NP_032799
	Wikidata
View/Edit Human	View/Edit Mouse

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.^[5]^[6]

The product of this gene, P2Y₂ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175591 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032860 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT (May 1994). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc Natl Acad Sci USA. 91 (8): 3275–9. Bibcode:1994PNAS...91.3275P. doi:10.1073/pnas.91.8.3275. PMC 43559. PMID 8159738.
^ Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Nov 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics. 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708.
^ "Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175591 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032860 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8159738-5] Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT (May 1994). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc Natl Acad Sci USA. 91 (8): 3275–9. Bibcode:1994PNAS...91.3275P. doi:10.1073/pnas.91.8.3275. PMC 43559. PMID 8159738.

[pmid9286708-6] Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Nov 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics. 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708.

[entrez-7] "Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2".

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