P2RY6

P2RY6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B6R
Identifiers
Aliases	P2RY6, P2Y6, pyrimidinergic receptor P2Y6
External IDs	OMIM: 602451; MGI: 2673874; HomoloGene: 14289; GeneCards: P2RY6; OMA:P2RY6 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	73,305,103 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	100,623,856 bp
RNA expression pattern
	Top expressed in
	spleen; ; placenta; ; right coronary artery; ; left coronary artery; ; gonad; ; appendix; ; human kidney; ; muscle of thigh; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	stroma of bone marrow; ; ascending aorta; ; aortic valve; ; mesenteric lymph nodes; ; calvaria; ; left colon; ; tunica media of zone of aorta; ; ankle; ; internal carotid artery; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled purinergic nucleotide receptor activity; G protein-coupled receptor activity; protein binding; G protein-coupled UDP receptor activity; signal transducer activity; G protein-coupled ADP receptor activity; G protein-coupled UTP receptor activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; integral component of plasma membrane; apical plasma membrane; membrane;
Biological process	positive regulation of smooth muscle cell migration; phospholipase C-activating G protein-coupled receptor signaling pathway; cellular response to organic cyclic compound; transepithelial chloride transport; signal transduction; G protein-coupled purinergic nucleotide receptor signaling pathway; cellular response to prostaglandin E stimulus; G protein-coupled receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of vascular associated smooth muscle cell proliferation; phagocytosis; activation of phospholipase C activity; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; positive regulation of inositol trisphosphate biosynthetic process; cellular response to purine-containing compound; cellular response to pyrimidine ribonucleotide;
	Sources:Amigo / QuickGO
Orthologs
	5031
	233571
	ENSG00000171631
	ENSMUSG00000048779
	Q15077
	Q9ERK9
NM_001277204; NM_001277205; NM_001277206; NM_001277207; NM_001277208;
	NM_004154; NM_176796; NM_176797; NM_176798
	NM_183168
NP_001264133; NP_001264134; NP_001264135; NP_001264136; NP_001264137;
	NP_789766; NP_789767; NP_789768
	NP_898991
	Wikidata
View/Edit Human	View/Edit Mouse

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171631 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048779 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Communi D, Parmentier M, Boeynaems JM (May 1996). "Cloning, functional expression and tissue distribution of the human P2Y6 receptor". Biochemical and Biophysical Research Communications. 222 (2): 303–8. doi:10.1006/bbrc.1996.0739. PMID 8670200.
^ "Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171631 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048779 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8670200-5] Communi D, Parmentier M, Boeynaems JM (May 1996). "Cloning, functional expression and tissue distribution of the human P2Y6 receptor". Biochemical and Biophysical Research Communications. 222 (2): 303–8. doi:10.1006/bbrc.1996.0739. PMID 8670200.

[entrez-6] "Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6".

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