| ATP P2X receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Figure 1. Schematic representation showing the membrane topology of a typical P2X receptor subunit. First and second transmembrane domains are labeled TM1 and TM2. | |||||||||
| Identifiers | |||||||||
| Symbol | P2X_receptor | ||||||||
| Pfam | PF00864 | ||||||||
| InterPro | IPR001429 | ||||||||
| PROSITE | PDOC00932 | ||||||||
| TCDB | 1.A.7 | ||||||||
| OPM superfamily | 181 | ||||||||
| OPM protein | 3h9v | ||||||||
| |||||||||
The P2X receptors, also ATP-gated P2X receptor cation channel family,[1] is a protein family that consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the ENaC/P2X superfamily.[1] ENaC and P2X receptors have similar 3-D structures and are homologous.[2] P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba.[3]
- ^ a b "ATP-gated P2X Receptor Cation Channel (P2X Receptor) Family". Functional and Phylogenetic Classification of Membrane Transport Proteins. Saier Lab. Group, UCSD and SDSC.
- ^ Chen JS, Reddy V, Chen JH, Shlykov MA, Zheng WH, Cho J, Yen MR, Saier MH (2011). "Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments". J. Mol. Microbiol. Biotechnol. 21 (3–4): 83–96. doi:10.1159/000334611. PMC 3290041. PMID 22286036.
- ^ Cite error: The named reference
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