Protein family
The p300-CBP coactivator family in humans is composed of two closely related transcriptional co-activating proteins (or coactivators):
- p300 (also called EP300 or E1A binding protein p300)
- CBP (also known as CREB-binding protein or CREBBP)
Both p300 and CBP interact with numerous transcription factors and act to increase the expression of their target genes.[2][3]
- ^ PDB: 3BIY; Liu X, Wang L, Zhao K, Thompson PR, Hwang Y, Marmorstein R, Cole PA (Feb 2008). "The structural basis of protein acetylation by the p300/CBP transcriptional coactivator". Nature. 451 (7180): 846–50. Bibcode:2008Natur.451..846L. doi:10.1038/nature06546. PMID 18273021. S2CID 4426988.
- ^ Kasper LH, Fukuyama T, Biesen MA, Boussouar F, Tong C, de Pauw A, Murray PJ, van Deursen JM, Brindle PK (Feb 2006). "Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development". Molecular and Cellular Biology. 26 (3): 789–809. doi:10.1128/MCB.26.3.789-809.2006. PMC 1347027. PMID 16428436.
- ^ Vo N, Goodman RH (Apr 2001). "CREB-binding protein and p300 in transcriptional regulation". The Journal of Biological Chemistry. 276 (17): 13505–8. doi:10.1074/jbc.R000025200. PMID 11279224. S2CID 41294840.