PALB2

PALB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2W18, 3EU7
Identifiers
Aliases	PALB2, FANCN, PNCA3, partner and localizer of BRCA2
External IDs	OMIM: 610355; MGI: 3040695; HomoloGene: 11652; GeneCards: PALB2; OMA:PALB2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	23,641,310 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	121,732,208 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; buccal mucosa cell; ; gonad; ; testicle; ; Achilles tendon; ; ventricular zone; ; gingival epithelium; ; ganglionic eminence; ; amniotic fluid; ; mucosa of transverse colon;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; tail of embryo; ; hand; ; epiblast; ; spermatocyte; ; embryo; ; genital tubercle; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding;
Cellular component	nucleoplasm; nucleus;
Biological process	animal organ morphogenesis; somitogenesis; post-anal tail morphogenesis; cellular response to DNA damage stimulus; DNA recombination; mesoderm development; negative regulation of apoptotic process; in utero embryonic development; multicellular organism growth; embryonic organ development; inner cell mass cell proliferation; DNA repair; double-strand break repair via homologous recombination;
	Sources:Amigo / QuickGO
Orthologs
	79728
	233826
	ENSG00000083093
	ENSMUSG00000044702
	Q86YC2
	Q3U0P1
	NM_024675
NM_001081238; NM_001289842; NM_001289843; NM_001289844; NM_001289845;
	NM_172744
	NP_078951
	NP_001074707; NP_001276771; NP_001276772; NP_001276773; NP_001276774
	Wikidata
View/Edit Human	View/Edit Mouse

Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000083093 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044702 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PALB2 partner and localizer of BRCA2".
^ Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, et al. (June 2006). "Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2". Molecular Cell. 22 (6): 719–29. doi:10.1016/j.molcel.2006.05.022. PMID 16793542.
^ Xia B, Dorsman JC, Ameziane N, de Vries Y, Rooimans MA, Sheng Q, et al. (February 2007). "Fanconi anemia is associated with a defect in the BRCA2 partner PALB2". Nature Genetics. 39 (2): 159–61. doi:10.1038/ng1942. PMID 17200672. S2CID 36491877.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000083093 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044702 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PALB2 partner and localizer of BRCA2".

[pmid16793542-6] Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, et al. (June 2006). "Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2". Molecular Cell. 22 (6): 719–29. doi:10.1016/j.molcel.2006.05.022. PMID 16793542.

[pmid17200672-7] Xia B, Dorsman JC, Ameziane N, de Vries Y, Rooimans MA, Sheng Q, et al. (February 2007). "Fanconi anemia is associated with a defect in the BRCA2 partner PALB2". Nature Genetics. 39 (2): 159–61. doi:10.1038/ng1942. PMID 17200672. S2CID 36491877.

[1]

[2]

[3]

[4]

[5]

[6]

[7]