PANO1

PANO1
Identifiers
Aliases	PANO1, PANO, proapoptotic nucleolar protein 1
External IDs	GeneCards: PANO1; OMA:PANO1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	799,190 bp
RNA expression pattern
	Top expressed in
	testicle; ; right hemisphere of cerebellum; ; stromal cell of endometrium; ; pituitary gland; ; body of pancreas; ; anterior pituitary; ; right lobe of liver; ; granulocyte; ; primary visual cortex; ; superior frontal gyrus;
	n/a
	More reference expression data
	n/a
Orthologs
	101927423
	n/a
	ENSG00000288675
	n/a
	I0J062
	n/a
	NM_001293167
	n/a
	NP_001280096
	n/a
	Wikidata
View/Edit Human

PANO1 is a protein which in humans is encoded by the PANO1 gene. PANO1 is an apoptosis inducing protein that is able to regulate the function of tumor suppressor.^[3] More specifically, P14ARF is a protein in which in humans is modulated by the PANO1 gene. P14ARF is known to function as a tumor suppressor.^[4] When PANO1 is highly expressed in the cells, it is able to modulate p14ARF by stabilizing it and protecting it from degradation.^[4] With a confidence level of 5 out of 5, PANO1 has been theorized to be expressed in the nucleolus of the cell.^[5] PANO1 is an intron-less gene.^[3] Intron-less genes only make up about 3% of the human genome.^[6] A functional analysis of these types of genes revealed that they often have tissue-specific expression in tissues such as the nervous system and testis.^[6] This kind of expression is commonly associated with neuropathies, disease, and cancer.^[6] The tissue types that PANO1 has the highest expression in, are the cerebellum regions of the brain as well as pituitary and testis tissues.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000288675 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "PANO1 - Proapoptotic nucleolar protein 1 - Homo sapiens (Human) - PANO1 gene & protein". www.uniprot.org. Retrieved 2021-08-01.
^ ^a ^b Watari A, Li Y, Higashiyama S, Yutsudo M (February 2012). "A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF". Exp Cell Res. 318 (3): 187–95. doi:10.1016/j.yexcr.2011.10.019. PMID 22094112.
^ "PANO1". www.genecards.org. Retrieved 2021-07-30.
^ ^a ^b ^c Grzybowska EA (July 2012). "Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing". Biochem Biophys Res Commun. 424 (1): 1–6. doi:10.1016/j.bbrc.2012.06.092. PMID 22732409.
^ "Human BLAT Search". genome.ucsc.edu. Retrieved 2021-08-01.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000288675 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:1-3] "PANO1 - Proapoptotic nucleolar protein 1 - Homo sapiens (Human) - PANO1 gene & protein". www.uniprot.org. Retrieved 2021-08-01.

[pmid22094112-4] Watari A, Li Y, Higashiyama S, Yutsudo M (February 2012). "A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF". Exp Cell Res. 318 (3): 187–95. doi:10.1016/j.yexcr.2011.10.019. PMID 22094112.

[:2-5] "PANO1". www.genecards.org. Retrieved 2021-07-30.

[pmid22732409-6] Grzybowska EA (July 2012). "Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing". Biochem Biophys Res Commun. 424 (1): 1–6. doi:10.1016/j.bbrc.2012.06.092. PMID 22732409.

[:3-7] "Human BLAT Search". genome.ucsc.edu. Retrieved 2021-08-01.

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