Mammalian protein found in Homo sapiens
PANO1 is a protein which in humans is encoded by the PANO1 gene. PANO1 is an apoptosis inducing protein that is able to regulate the function of tumor suppressor.[3] More specifically, P14ARF is a protein in which in humans is modulated by the PANO1 gene. P14ARF is known to function as a tumor suppressor.[4] When PANO1 is highly expressed in the cells, it is able to modulate p14ARF by stabilizing it and protecting it from degradation.[4] With a confidence level of 5 out of 5, PANO1 has been theorized to be expressed in the nucleolus of the cell.[5] PANO1 is an intron-less gene.[3] Intron-less genes only make up about 3% of the human genome.[6] A functional analysis of these types of genes revealed that they often have tissue-specific expression in tissues such as the nervous system and testis.[6] This kind of expression is commonly associated with neuropathies, disease, and cancer.[6] The tissue types that PANO1 has the highest expression in, are the cerebellum regions of the brain as well as pituitary and testis tissues.[7]