PAX2

PAX2
Identifiers
Aliases	PAX2, PAPRS, FSGS7, paired box 2, PAX-2
External IDs	OMIM: 167409; MGI: 97486; HomoloGene: 2968; GeneCards: PAX2; OMA:PAX2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	100,829,944 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	44,837,871 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; right uterine tube; ; human kidney; ; tail of epididymis; ; corpus epididymis; ; seminal vesicula; ; endometrium; ; testicle; ; paraflocculus of cerebellum; ; kidney tubule;
	Top expressed in
	mesonephros; ; mesonephric tubules; ; mesonephric duct; ; optic stalk; ; ureteric bud; ; otic placode; ; neural ectoderm; ; epithelium of epididymis; ; Gray matter of spinal cord; ; optic recess;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; superoxide-generating NAD(P)H oxidase activity; transcription factor binding; cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	Golgi apparatus; centriolar satellite; microtubule organizing center; protein-DNA complex; nucleolus; lysosome; nucleus; protein-containing complex;
Biological process	cellular response to hydrogen peroxide; cellular response to glucose stimulus; cochlea development; pronephros development; cellular response to retinoic acid; regulation of metanephric nephron tubule epithelial cell differentiation; animal organ development; ureter development; cell differentiation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of branching involved in ureteric bud morphogenesis; regulation of transcription, DNA-templated; positive regulation of metanephric DCT cell differentiation; regulation of metanephros size; axonogenesis; protein kinase B signaling; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis; negative regulation of apoptotic process involved in metanephric collecting duct development; positive regulation of epithelial cell proliferation; optic nerve morphogenesis; pronephric field specification; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; metanephric mesenchymal cell differentiation; human ageing; metanephric epithelium development; mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of apoptotic process; glial cell differentiation; transcription by RNA polymerase II; retinal pigment epithelium development; nephric duct formation; transcription, DNA-templated; stem cell differentiation; metanephric distal convoluted tubule development; reactive oxygen species metabolic process; negative regulation of mesenchymal cell apoptotic process involved in metanephros development; mesonephros development; optic nerve structural organization; positive regulation of transcription, DNA-templated; cellular response to epidermal growth factor stimulus; metanephric nephron tubule formation; positive regulation of metanephric glomerulus development; multicellular organism development; branching involved in ureteric bud morphogenesis; neural tube closure; response to nutrient levels; negative regulation of apoptotic process involved in metanephric nephron tubule development; ureter maturation; inner ear morphogenesis; cochlea morphogenesis; positive regulation of optic nerve formation; positive regulation of cell population proliferation; optic cup morphogenesis involved in camera-type eye development; urogenital system development; cell fate determination; negative regulation of programmed cell death; vestibulocochlear nerve formation; camera-type eye development; metanephric collecting duct development; negative regulation of reactive oxygen species metabolic process; mesodermal cell fate specification; negative regulation of transcription, DNA-templated; metanephric mesenchyme development; optic chiasma development; optic nerve development; positive regulation of transcription by RNA polymerase II; visual perception; negative regulation of cytolysis; brain morphogenesis; mesenchymal to epithelial transition;
	Sources:Amigo / QuickGO
Orthologs
	5076
	18504
	ENSG00000075891
	ENSMUSG00000004231
	Q02962; Q5SZP1
	P32114
NM_003990; NM_000278; NM_001304569; NM_003987; NM_003988;
	NM_003989; NM_001374303
	NM_011037
NP_000269; NP_001291498; NP_003978; NP_003979; NP_003980;
	NP_003981; NP_001361232
NP_035167; NP_001355672; NP_001355673; NP_001355674; NP_001355675;
	NP_001355676; NP_001355677; NP_001355678; NP_001355679; NP_001355680
	Wikidata
View/Edit Human	View/Edit Mouse

Paired box gene 2, also known as Pax-2, is a protein which in humans is encoded by the PAX2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075891 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004231 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pilz AJ, Povey S, Gruss P, Abbott CM (1993). "Mapping of the human homologs of the murine paired-box-containing genes". Mammalian Genome. 4 (2): 78–82. doi:10.1007/BF00290430. PMID 8431641. S2CID 30845070.
^ Stapleton P, Weith A, Urbánek P, Kozmik Z, Busslinger M (Apr 1993). "Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9". Nature Genetics. 3 (4): 292–8. doi:10.1038/ng0493-292. PMID 7981748. S2CID 21338655.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075891 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004231 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8431641-5] Pilz AJ, Povey S, Gruss P, Abbott CM (1993). "Mapping of the human homologs of the murine paired-box-containing genes". Mammalian Genome. 4 (2): 78–82. doi:10.1007/BF00290430. PMID 8431641. S2CID 30845070.

[pmid7981748-6] Stapleton P, Weith A, Urbánek P, Kozmik Z, Busslinger M (Apr 1993). "Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9". Nature Genetics. 3 (4): 292–8. doi:10.1038/ng0493-292. PMID 7981748. S2CID 21338655.

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