PAX4

PAX4
Identifiers
Aliases	PAX4, KPD, MODY9, paired box 4
External IDs	OMIM: 167413; MGI: 97488; HomoloGene: 4515; GeneCards: PAX4; OMA:PAX4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	127,618,142 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	28,449,352 bp
RNA expression pattern
	Top expressed in
	testicle; ; rectum; ; mucosa of transverse colon; ; duodenum; ; tibialis anterior muscle; ; deltoid muscle; ; islet of Langerhans; ; developmental structure; ; embryo; ; ganglionic eminence;
	Top expressed in
	entorhinal cortex; ; CA3 field; ; perirhinal cortex; ; embryo; ; embryo; ; medulla oblongata; ; inner muscle layer; ; ureter; ; lens; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding;
Cellular component	nucleoplasm; nucleus;
Biological process	cell differentiation; regulation of transcription, DNA-templated; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; retina development in camera-type eye; circadian rhythm; positive regulation of cell differentiation; animal organ morphogenesis; regulation of cell differentiation; response to cAMP; negative regulation of transcription, DNA-templated; endocrine pancreas development; pancreas development;
	Sources:Amigo / QuickGO
Orthologs
	5078
	18506
	ENSG00000106331
	ENSMUSG00000029706
	O43316; Q3KNR5
	P32115
	NM_006193; NM_001366110; NM_001366111
	NM_001159925; NM_001159926; NM_011038
	NP_006184; NP_001353039; NP_001353040
	NP_001153397; NP_001153398; NP_035168
	Wikidata
View/Edit Human	View/Edit Mouse

Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106331 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029706 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PAX4 paired box gene 4".
^ Matsushita T, Yamaoka T, Otsuka S, Moritani M, Matsumoto T, Itakura M (Jan 1998). "Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4". Biochemical and Biophysical Research Communications. 242 (1): 176–80. doi:10.1006/bbrc.1997.7935. PMID 9439631.
^ Inoue H, Nomiyama J, Nakai K, Matsutani A, Tanizawa Y, Oka Y (Feb 1998). "Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue". Biochemical and Biophysical Research Communications. 243 (2): 628–33. doi:10.1006/bbrc.1998.8144. PMID 9480859.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106331 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029706 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PAX4 paired box gene 4".

[pmid9439631-6] Matsushita T, Yamaoka T, Otsuka S, Moritani M, Matsumoto T, Itakura M (Jan 1998). "Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4". Biochemical and Biophysical Research Communications. 242 (1): 176–80. doi:10.1006/bbrc.1997.7935. PMID 9439631.

[pmid9480859-7] Inoue H, Nomiyama J, Nakai K, Matsutani A, Tanizawa Y, Oka Y (Feb 1998). "Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue". Biochemical and Biophysical Research Communications. 243 (2): 628–33. doi:10.1006/bbrc.1998.8144. PMID 9480859.

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