PAX8

PAX8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K27
Identifiers
Aliases	PAX8, paired box 8, PAX-8
External IDs	OMIM: 167415; MGI: 97492; HomoloGene: 2589; GeneCards: PAX8; OMA:PAX8 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	113,278,921 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	24,365,611 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube; ; renal medulla; ; caput epididymis; ; corpus epididymis; ; human kidney; ; tail of epididymis; ; tibialis anterior muscle; ; mucosa of ileum;
	Top expressed in
	thyroid gland; ; right kidney; ; proximal tubule; ; inner renal medulla; ; connecting tubule; ; human kidney; ; lumbar subsegment of spinal cord; ; inner stripe of outer renal medulla; ; uterus; ; otic pit;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; thyroid-stimulating hormone receptor activity; protein binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	regulation of apoptotic process; pronephros development; regulation of metanephric nephron tubule epithelial cell differentiation; cell differentiation; mesonephric tubule development; positive regulation of branching involved in ureteric bud morphogenesis; kidney epithelium development; regulation of transcription, DNA-templated; positive regulation of metanephric DCT cell differentiation; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis; negative regulation of apoptotic process involved in metanephric collecting duct development; kidney development; pronephric field specification; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; anatomical structure morphogenesis; metanephric epithelium development; mesenchymal to epithelial transition involved in metanephros morphogenesis; transcription by RNA polymerase II; regulation of thyroid-stimulating hormone secretion; transcription, DNA-templated; otic vesicle development; metanephric distal convoluted tubule development; negative regulation of mesenchymal cell apoptotic process involved in metanephros development; mesonephros development; positive regulation of transcription, DNA-templated; metanephric nephron tubule formation; multicellular organism development; central nervous system development; metanephric comma-shaped body morphogenesis; branching involved in ureteric bud morphogenesis; thyroid gland development; positive regulation of thyroid hormone generation; negative regulation of apoptotic process involved in metanephric nephron tubule development; S-shaped body morphogenesis; inner ear morphogenesis; urogenital system development; sulfur compound metabolic process; metanephric S-shaped body morphogenesis; metanephros development; cellular response to gonadotropin stimulus; positive regulation of transcription by RNA polymerase II; thyroid-stimulating hormone signaling pathway; negative regulation of cardiac muscle cell apoptotic process; ventricular septum development;
	Sources:Amigo / QuickGO
Orthologs
	7849
	18510
	ENSG00000125618
	ENSMUSG00000026976
	Q06710
	Q00288
	NM_003466; NM_013951; NM_013952; NM_013953; NM_013992
	NM_011040
	NP_003457; NP_039246; NP_039247; NP_054698
	NP_035170
	Wikidata
View/Edit Human	View/Edit Mouse

Paired box gene 8, also known as PAX8, is a protein which in humans is encoded by the PAX8 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026976 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PAX8 paired box gene 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026976 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PAX8 paired box gene 8".

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