PCDH1

PCDH1
Identifiers
Aliases	PCDH1, PC42, PCDH42, protocadherin 1
External IDs	OMIM: 603626; MGI: 104692; HomoloGene: 12613; GeneCards: PCDH1; OMA:PCDH1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	141,879,246 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	38,345,106 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; beta cell; ; mucosa of transverse colon; ; right lung; ; minor salivary glands; ; skin of arm; ; apex of heart; ; upper lobe of left lung; ; skin of leg; ; olfactory zone of nasal mucosa;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; esophagus; ; lip; ; primary visual cortex; ; yolk sac; ; genital tubercle; ; tail of embryo; ; intestinal villus; ; epithelium of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cell-cell junction; nucleus; nucleolus; cell junction; intracellular membrane-bounded organelle;
Biological process	cell-cell signaling; cell adhesion; nervous system development; homophilic cell adhesion via plasma membrane adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	5097
	75599
	ENSG00000156453
	ENSMUSG00000051375
	Q08174
	n/a
	NM_001278613; NM_001278615; NM_002587; NM_032420
	NM_029357
	NP_001265542; NP_001265544; NP_002578; NP_115796
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene.^[5]^[6]

This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracellular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051375 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S (Jul 1993). "Protocadherins: a large family of cadherin-related molecules in central nervous system". EMBO J. 12 (6): 2249–56. doi:10.1002/j.1460-2075.1993.tb05878.x. PMC 413453. PMID 8508762.
^ ^a ^b "Entrez Gene: PCDH1 protocadherin 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156453 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051375 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8508762-5] Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S (Jul 1993). "Protocadherins: a large family of cadherin-related molecules in central nervous system". EMBO J. 12 (6): 2249–56. doi:10.1002/j.1460-2075.1993.tb05878.x. PMC 413453. PMID 8508762.

[entrez-6] "Entrez Gene: PCDH1 protocadherin 1".

[1]

[2]

[3]

[4]

[5]

[6]