PCDH10

PCDH10
Identifiers
Aliases	PCDH10, OL-PCDH, PCDH19, protocadherin 10
External IDs	OMIM: 608286; MGI: 1338042; HomoloGene: 74967; GeneCards: PCDH10; OMA:PCDH10 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	133,208,606 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	45,390,058 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; prefrontal cortex; ; internal globus pallidus; ; Brodmann area 46; ; caudate nucleus; ; nucleus accumbens; ; superior frontal gyrus; ; Brodmann area 23; ; stromal cell of endometrium; ; putamen;
	Top expressed in
	substantia nigra; ; olfactory tubercle; ; lateral hypothalamus; ; globus pallidus; ; dorsomedial hypothalamic nucleus; ; primary motor cortex; ; superior frontal gyrus; ; paraventricular nucleus of hypothalamus; ; nucleus accumbens; ; medial dorsal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	homophilic cell adhesion via plasma membrane adhesion molecules; cell adhesion; cell-cell signaling; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	57575
	18526
	ENSG00000138650
	ENSMUSG00000049100
	Q9P2E7
	n/a
	NM_020815; NM_032961
	NM_001098170; NM_001098171; NM_001098172; NM_011043
	NP_065866; NP_116586
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-10 is a protein that in humans is encoded by the PCDH10 gene.^[5]^[6]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138650 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049100 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
^ ^a ^b "Entrez Gene: PCDH10 protocadherin 10".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138650 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049100 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10835267-5] Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.

[entrez-6] "Entrez Gene: PCDH10 protocadherin 10".

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