PCDH18

PCDH18
Identifiers
Aliases	PCDH18, PCDH68L, protocadherin 18
External IDs	OMIM: 608287; MGI: 1920423; HomoloGene: 10389; GeneCards: PCDH18; OMA:PCDH18 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	137,532,494 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	49,711,774 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Achilles tendon; ; parietal pleura; ; lactiferous duct; ; mucosa of ileum; ; retinal pigment epithelium; ; tibia; ; placenta; ; skin of hip; ; visceral pleura;
	Top expressed in
	hand; ; maxillary prominence; ; genital tubercle; ; mandibular prominence; ; dermis; ; human fetus; ; left lung lobe; ; molar; ; Gonadal ridge; ; foot;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	brain development; homophilic cell adhesion via plasma membrane adhesion molecules; cell adhesion; cell-cell signaling; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	54510
	73173
	ENSG00000189184
	ENSMUSG00000037892
	Q9HCL0
	Q8VHR0
	NM_001300828; NM_019035
	NM_130448
	NP_001287757; NP_061908
NP_569715; NP_001391291; NP_001391292; NP_001391293; NP_001391295;
	NP_001391296; NP_001391306
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.^[5]^[6]^[7]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000189184 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037892 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
^ Wolverton T, Lalande M (Sep 2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics. 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318.
^ ^a ^b "Entrez Gene: PCDH18 protocadherin 18".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000189184 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037892 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10835267-5] Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.

[pmid11549318-6] Wolverton T, Lalande M (Sep 2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics. 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318.

[entrez-7] "Entrez Gene: PCDH18 protocadherin 18".

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