PCDHGA11

PCDHGA11
Identifiers
Aliases	PCDHGA11, PCDH-GAMMA-A11, protocadherin gamma subfamily A, 11
External IDs	OMIM: 606298; MGI: 1935228; HomoloGene: 110934; GeneCards: PCDHGA11; OMA:PCDHGA11 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	141,512,975 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	37,974,926 bp
RNA expression pattern
	Top expressed in
	testicle; ; stromal cell of endometrium; ; ventricular zone; ; ganglionic eminence; ; Achilles tendon; ; sural nerve; ; apex of heart; ; left ventricle; ; right coronary artery; ; Descending thoracic aorta;
	Top expressed in
	ganglionic eminence; ; olfactory bulb; ; hippocampus proper; ; striatum of neuraxis; ; mesencephalon; ; rhombencephalon; ; neural tube; ; cerebellum; ; dentate gyrus of hippocampal formation granule cell; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	homophilic cell adhesion via plasma membrane adhesion molecules; cell adhesion; cell-cell signaling; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	56105
	93723
	ENSG00000253873
	ENSMUSG00000102742
	Q9Y5H2
	Q91XY8
	NM_032092; NM_018914; NM_032091
	NM_033594
	NP_061737; NP_114480; NP_114481
	NP_291072
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin gamma-A11 is a protein that in humans is encoded by the PCDHGA11 gene.^[5]^[6]

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome 5. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.

The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region.

These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000253873 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000102742 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
^ ^a ^b "Entrez Gene: PCDHGA11 protocadherin gamma subfamily A, 11".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000253873 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000102742 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10380929-5] Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.

[entrez-6] "Entrez Gene: PCDHGA11 protocadherin gamma subfamily A, 11".

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