PCLO

PCLO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UJD
Identifiers
Aliases	PCLO, ACZ, PCH3, piccolo presynaptic cytomatrix protein
External IDs	OMIM: 604918; MGI: 1349390; HomoloGene: 69111; GeneCards: PCLO; OMA:PCLO - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	83,162,930 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	14,913,473 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; cerebellar vermis; ; orbitofrontal cortex; ; Region I of hippocampus proper; ; endothelial cell; ; frontal pole; ; entorhinal cortex; ; Brodmann area 46; ; superior frontal gyrus;
	Top expressed in
	cingulate gyrus; ; primary motor cortex; ; prefrontal cortex; ; subiculum; ; medial dorsal nucleus; ; temporal lobe; ; amygdala; ; superior cervical ganglion; ; olfactory tubercle; ; piriform cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium-dependent phospholipid binding; profilin binding; calcium ion binding; metal ion binding; structural constituent of presynaptic active zone;
Cellular component	presynaptic active zone; cell junction; synapse; cytoskeleton; extracellular exosome; membrane; postsynaptic density; cytoskeleton of presynaptic active zone; presynaptic active zone cytoplasmic component;
Biological process	regulation of exocytosis; synapse assembly; insulin secretion; cytoskeleton organization; cAMP-mediated signaling; synaptic vesicle exocytosis; protein localization to synapse; presynapse to nucleus signaling pathway; maintenance of presynaptic active zone structure; synaptic vesicle clustering;
	Sources:Amigo / QuickGO
Orthologs
	27445
	26875
	ENSG00000186472
	ENSMUSG00000061601
	Q9Y6V0
	Q9QYX7
	NM_033026; NM_014510
	NM_001110796; NM_011995
	NP_055325; NP_149015
	NP_001104266; NP_036125
	Wikidata
View/Edit Human	View/Edit Mouse

Protein piccolo is a protein that in humans is encoded by the PCLO gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186472 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061601 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cases-Langhoff C, Voss B, Garner AM, Appeltauer U, Takei K, Kindler S, Veh RW, De Camilli P, Gundelfinger ED, Garner CC (Mar 1996). "Piccolo, a novel 420 kDa protein associated with the presynaptic cytomatrix". European Journal of Cell Biology. 69 (3): 214–23. PMID 8900486.
^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. CiteSeerX 10.1.1.610.1181. doi:10.1093/dnares/5.1.31. PMID 9628581.
^ "Entrez Gene: PCLO piccolo (presynaptic cytomatrix protein)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186472 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000061601 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8900486-5] Cases-Langhoff C, Voss B, Garner AM, Appeltauer U, Takei K, Kindler S, Veh RW, De Camilli P, Gundelfinger ED, Garner CC (Mar 1996). "Piccolo, a novel 420 kDa protein associated with the presynaptic cytomatrix". European Journal of Cell Biology. 69 (3): 214–23. PMID 8900486.

[pmid9628581-6] Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. CiteSeerX 10.1.1.610.1181. doi:10.1093/dnares/5.1.31. PMID 9628581.

[entrez-7] "Entrez Gene: PCLO piccolo (presynaptic cytomatrix protein)".

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