PCM1

PCM1
Identifiers
Aliases	PCM1, PTC4, RET/PCM-1, pericentriolar material 1
External IDs	OMIM: 600299; MGI: 1277958; HomoloGene: 4518; GeneCards: PCM1; OMA:PCM1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	41,332,344 bp
RNA expression pattern
	n/a
	Top expressed in
	spermatocyte; ; genital tubercle; ; tail of embryo; ; saccule; ; ventricular zone; ; spermatid; ; otic placode; ; ascending aorta; ; zygote; ; otic vesicle;
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding;
Cellular component	ciliary basal body; cell projection; nuclear membrane; membrane; microtubule organizing center; centriole; cytoskeleton; ciliary transition zone; centrosome; centriolar satellite; pericentriolar material; cytoplasm; cytosol; apical part of cell; non-motile cilium; protein-containing complex;
Biological process	positive regulation of intracellular protein transport; neuron migration; neuronal stem cell population maintenance; intraciliary transport involved in cilium assembly; cell projection organization; G2/M transition of mitotic cell cycle; cytoplasmic microtubule organization; negative regulation of neurogenesis; interkinetic nuclear migration; microtubule anchoring at centrosome; protein localization to centrosome; microtubule anchoring; social behavior; cilium assembly; ciliary basal body-plasma membrane docking; non-motile cilium assembly; centrosome cycle; regulation of G2/M transition of mitotic cell cycle; protein localization to organelle;
	Sources:Amigo / QuickGO
Orthologs
	5108
	18536
	ENSG00000078674
	ENSMUSG00000031592
	Q15154
	Q9R0L6
	NM_006197; NM_001315507; NM_001315508
	NM_023662
NP_001302436; NP_001302437; NP_006188; NP_001339561; NP_001339562;
	NP_001339563; NP_001339564; NP_001339565; NP_001339566; NP_001339567; NP_001339568; NP_001339569; NP_001339570; NP_001339571; NP_001339572; NP_001339573; NP_001339574; NP_001339575; NP_001339576; NP_001339577; NP_001339578; NP_001339579; NP_001339580; NP_001339581; NP_001339582; NP_001339583; NP_001339584; NP_001339585; NP_001339586; NP_001339587; NP_001339588; NP_001339589; NP_001302436.1
NP_076151; NP_001390746; NP_001390748; NP_001390749; NP_001390752;
	NP_001390753; NP_001390754
	Wikidata
View/Edit Human	View/Edit Mouse

Pericentriolar material 1, also known as PCM1, is a protein which in humans is encoded by the PCM1 gene.^[4]^[5]^[6]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031592 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PCM1 pericentriolar material 1".
^ Balczon R, Bao L, Zimmer WE (March 1994). "PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution". J. Cell Biol. 124 (5): 783–93. doi:10.1083/jcb.124.5.783. PMC 2119948. PMID 8120099.
^ Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM (April 2005). "Dynamic Recruitment of Nek2 Kinase to the Centrosome Involves Microtubules, PCM-1, and Localized Proteasomal Degradation". Mol. Biol. Cell. 16 (4): 1711–24. doi:10.1091/mbc.E04-08-0688. PMC 1073654. PMID 15659651.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000031592 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: PCM1 pericentriolar material 1".

[pmid8120099-5] Balczon R, Bao L, Zimmer WE (March 1994). "PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution". J. Cell Biol. 124 (5): 783–93. doi:10.1083/jcb.124.5.783. PMC 2119948. PMID 8120099.

[pmid15659651-6] Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM (April 2005). "Dynamic Recruitment of Nek2 Kinase to the Centrosome Involves Microtubules, PCM-1, and Localized Proteasomal Degradation". Mol. Biol. Cell. 16 (4): 1711–24. doi:10.1091/mbc.E04-08-0688. PMC 1073654. PMID 15659651.

[1]

[2]

[3]

[4]

[5]

[6]