PCSK7

PCSK7
Identifiers
Aliases	PCSK7, LPC, PC7, PC8, SPC7, proprotein convertase subtilisin/kexin type 7
External IDs	OMIM: 604872; MGI: 107421; HomoloGene: 37955; GeneCards: PCSK7; OMA:PCSK7 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	117,232,525 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,841,024 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; sural nerve; ; mucosa of transverse colon; ; gastric mucosa; ; left uterine tube; ; body of stomach; ; epithelium of colon; ; buccal mucosa cell; ; lymph node; ; rectum;
	Top expressed in
	granulocyte; ; neural layer of retina; ; spermatocyte; ; large intestine; ; right kidney; ; colon; ; submandibular gland; ; epithelium of stomach; ; lip; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity;
Cellular component	integral component of membrane; integral component of Golgi membrane; Golgi apparatus; membrane; trans-Golgi network;
Biological process	protein processing; peptide hormone processing; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	9159
	18554
	ENSG00000160613
	ENSMUSG00000035382
	Q16549
	Q61139
	NM_004716
	NM_001281934; NM_008794
	NP_004707
	NP_001268863; NP_032820
	Wikidata
View/Edit Human	View/Edit Mouse

Proprotein convertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene.^[5]^[6]^[7]

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140.

This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160613 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035382 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bruzzaniti A, Goodge K, Jay P, Taviaux SA, Lam MH, Berta P, Martin TJ, Moseley JM, Gillespie MT (Jun 1996). "C8, a new member of the convertase family". Biochem J. 314 ( Pt 3) (Pt 3): 727–31. doi:10.1042/bj3140727. PMC 1217117. PMID 8615762.
^ Goodge KA, Thomas RJ, Martin TJ, Gillespie MT (Jan 1999). "Gene organization and alternative splicing of human prohormone convertase PC8". Biochem J. 336 ( Pt 2) (Pt 2): 353–9. doi:10.1042/bj3360353. PMC 1219878. PMID 9820811.
^ ^a ^b "Entrez Gene: PCSK7 proprotein convertase subtilisin/kexin type 7".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160613 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035382 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8615762-5] Bruzzaniti A, Goodge K, Jay P, Taviaux SA, Lam MH, Berta P, Martin TJ, Moseley JM, Gillespie MT (Jun 1996). "C8, a new member of the convertase family". Biochem J. 314 ( Pt 3) (Pt 3): 727–31. doi:10.1042/bj3140727. PMC 1217117. PMID 8615762.

[pmid9820811-6] Goodge KA, Thomas RJ, Martin TJ, Gillespie MT (Jan 1999). "Gene organization and alternative splicing of human prohormone convertase PC8". Biochem J. 336 ( Pt 2) (Pt 2): 353–9. doi:10.1042/bj3360353. PMC 1219878. PMID 9820811.

[entrez-7] "Entrez Gene: PCSK7 proprotein convertase subtilisin/kexin type 7".

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