Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.[4][5]
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing's disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.[5]
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075270 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303. PMID 10725373.
- ^ a b "Entrez Gene: PDE11A phosphodiesterase 11A".