PDE1B

PDE1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TAZ, 4NPV, 4NPW, 5B25
Identifiers
Aliases	PDE1B, PDE1B1, PDES1B, HEL-S-79p, phosphodiesterase 1B
External IDs	OMIM: 171891; MGI: 97523; HomoloGene: 37370; GeneCards: PDE1B; OMA:PDE1B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	54,579,239 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	103,438,479 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; gastric mucosa; ; right frontal lobe; ; prefrontal cortex; ; Descending thoracic aorta; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; superior frontal gyrus; ; globus pallidus; ; ventricular zone; ; perirhinal cortex; ; granulocyte; ; entorhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity; metal ion binding; calmodulin binding; cyclic-nucleotide phosphodiesterase activity; calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; protein binding; phosphoric diester hydrolase activity; hydrolase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity;
Cellular component	cytoplasm; soma; cytosol;
Biological process	visual learning; regulation of neurotransmitter levels; cAMP catabolic process; locomotory behavior; response to amphetamine; serotonin metabolic process; monocyte differentiation; regulation of dopamine metabolic process; cellular response to macrophage colony-stimulating factor stimulus; cGMP catabolic process; cellular response to granulocyte macrophage colony-stimulating factor stimulus; apoptotic process; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5153
	18574
	ENSG00000123360
	ENSMUSG00000022489
	Q01064
	Q01065
NM_000924; NM_001165975; NM_001288768; NM_001288769; NM_001315534;
	NM_001315535
	NM_001285890; NM_008800; NM_001357980
NP_000915; NP_001159447; NP_001275697; NP_001275698; NP_001302463;
	NP_001302464
	NP_001272819; NP_032826; NP_001344909
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123360 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022489 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A. 93 (20): 11236–41. Bibcode:1996PNAS...9311236J. doi:10.1073/pnas.93.20.11236. PMC 1074519. PMID 8855339.
^ Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal. 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816.
^ "Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123360 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022489 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8855339-5] Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A. 93 (20): 11236–41. Bibcode:1996PNAS...9311236J. doi:10.1073/pnas.93.20.11236. PMC 1074519. PMID 8855339.

[pmid9419816-6] Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal. 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816.

[entrez-7] "Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent".

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